Melphalan, an alkylating agent, is used for the treatment of multiple myeloma. While its mechanism of action is similar to other nitrogen mustards, it causes less mucosal damage than other alkylating agents …doi:10.1016/B978-008055232-3.62124-5Barbara J. Rider...
[Pharmacological action] This product is a L-phenylalanine mustard, its anti-cancer effect is strong according to PAM, its mechanism of action is the same as HN2, also a cell cycle non-specific drug.【Indications】 This product can be used as a drug of choice for multiple myeloma in a ...
A link to download a PDF version of the drug profile will be included in your email receipt. At a glance Originator Oncopeptides Class Amides; Amines; Antineoplastics; Chlorinated hydrocarbons; Esters; Fluorobenzenes; Peptide drug conjugates Mechanism of Action Alkylating agents Orphan Drug ...
Mechanism of Action Melphalan can act either as monofunctional (one alkylating moiety) or bifunctional (two alkylating moieties). Bifunctional melphalan has the capacity to crosslink both interstrand and intrastrand in DNA. After administration, alkylating agents get converted into carbonium ions, and re...
Because macrophages have been implicated as major players in the mechanism of action of rituximab, we have investigated the factors that modulate their tum... M Leidi,E Gotti,L Bologna,... - 《Journal of Immunology》 被引量: 1219发表: 2009年 A phase II trial of trastuzumab in combination ...
Thus, although the active metabolite, isophosphoramide mustard, is generated from the 4-hydroxy derivative by the same mechanism described for cyclophosphamide, this hydroxylation is slower than that of the chloroethyl side chains attached to the exocyclic nitrogen, probably because of steric hindrance...
. The mechanism of ice chips' action is vasoconstriction, which stops the inflammation in the region of the oral cavity mucosa and reduces the contact of toxic drugs with the mucous layer10. The AHSCT in multiple myeloma might be a spot-on indication for cryotherapy as melphalan used as a ...
Mateos MV, Oriol A, Larocca A, et al. HORIZON (OP-106): an exploratory analysis of time-tonext treatment (TTNT) in patients (pts) with relapsed/refractory multiple myeloma (RRMM) who received melflufen plus dexamethasone (dex).J Clin Oncol. 2020;38(suppl 15):e20570. doi:10.1200/jco....
As the mechanism by which melphalan impairs cardiac cells remains poorly understood, here, we aimed to use cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) to investigate the cellular and molecular mechanisms of melphalan-induced cardiotoxicity. Methods hiPSC-CMs were ...
Regardless of the exact mechanism of unhooking, it is widely assumed that this unhooking step will be common to all DNA ICLs. In this study, however, we present evidence in vitro and in clinical samples with acquired resistance that the mechanisms of unhooking for melphalan and cisplatin-induced...