HSCT: How Does It Work? Letizia Galgano, Daphna Hutt, and Hilda Mekelenkamp 2 Abstract The HSCT (haematopoietic stem cell trans- plant) is a particular treatment for many hae- matological and non-haematological diseases. Broadly, there are three different categories of transplantation,...
Anthracycline chemotherapy attacks the enzymes inside cancer cells’ DNA that help them divide and grow. They work for many types of cancer. Some of these drugs are actinomycin-D, bleomycin, daunorubicin, and doxorubicin, among others. High doses of anti-tumor antibiotics can damage your heart o...
How Does Chemotherapy Work? In your body, cells naturally grow and multiply. Each cell makes a copy of its DNA and then splits into two new cells. This is called the cell cycle. Cells only multiply at certain times, and they die when they get old. This is normal and healthy. ...
In the 1960s, the introduction of combination therapy with melphalan and prednisone was the start of a new era of MM treatment.14 This regimen provided more durable responses and improved survival, making melphalan and prednisone the standard of care for decades. Despite these advances, the goal...
40 At our center, eligibility for stem cell transplant with full dose (200 mg/m2) melphalan requires the following: age <70 years, Eastern Cooperative Oncology Group performance status <2, NT-proBNP <5000 ng/L, troponin T <60 ng/L, left ventricular ejection fraction > 45%, New York ...
If the first line of therapeutics fails to control the disease, or in the event of relapses, there is an indication for hematopoietic stem cell autotransplantation after conditioning, which requires extremely gonadotoxic protocols such as BEAM (carmustine, etoposide, cytosine arabinoside, melphalan) ...
(b)the value of the goods imported does not exceed 5% of the FOB value of handicrafts exported during the preceding financial year; and (c)the importer produces a certificate from the Export Promotion Council for Handicrafts certifying the value of exports made during the financial year mentioned...
If a patient is not a candidate for an autologous transplant, the most common initial treatment is a combination of melphalan, a type of chemotherapy and prednisone, a type of corticosteroid . Cyclophosphamide and prednisone CP or other combinations of agents may also be used. High-dose dexametha...
HSCT: How Does It Work? Abstract The HSCT (haematopoietic stem cell transplant) is a particular treatment for many haematological and non-haematological diseases. Broadly, there are three different categories of transplantation, autologous, allogeneic and syngeneic, which can be applied to most disease...
The European Myeloma Network is initiating a prospective study in which pPCL patients will be treated with a novel agent-containing induction regimen, followed by tandem auto-SCT and allo-SCT, the latter involving semi-intensive conditioning with melphalan 140 mg/m2 + fludarabine, as well as novel...