The isolated, electrically stimulated guinea pig longitudinal muscle-myenteric plexus has proven to be an excellent model system for understanding the mode of action of morphine-type drugs in the CNS. These drugs block electrically-induced contractions by inhibiting release of acetylcholine. We have ...
mech´an`ism of ac´tion n.1.(Medicine, Biochemistry)The mechanism{2} by which a pharmacologically active substance produces an effect on a living organism or in a biochemical system; as, themechanism of actionof actinomycin involves its binding to DNA. The mechanism of action is usually ...
Myrrh also reduces the downregulation of suppresor of cytokine synthesis (SOCS) in response to interleukin-1beta and interferon-gamma. SOCS serves as an autoregulator of the JAK/STAT pathway under transcriptional control of STATs and inhibits activation of the pathway. Analgesic: Myrrh appears to ...
Deciphering the mechanism(s) of action of natural products: analgesic peroxide oil as example 喜欢 0 阅读量: 9 作者:R. B. Raffa,J. V. Pergolizzi Jr 摘要: SummaryBackground: There are multiple reports of natural products having therapeutic effect. In an era of evidence-based medicine, ...
It is well known that pain is one of the most important characteristics of migraine. Therefore, it is important and interesting to investigate the analgesic effect and mechanism of drugs which are used to treat migraine. Tou Feng Yu pill (TFY) is a traditional Chinese herbal medicine, consisti...
This drug was the first clinical useful drug in its class, and its approval was followed by the formulation of many other proton pump inhibitor drugs 6. Omeprazole is generally effective and well-tolerated, promoting its popular use in children and adults Label. Type Small Molecule Groups ...
of the disease, which involves autoimmunity, genetics, inflammation and oxidative stress in the body’s tissues, the current drug therapy generally targets a single molecule, and effective and efficient drugs involving multiple levels and targets are lacking; thus, there is an urgent need for high...
Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.
P.R. Kinchington, A.H. Dickenson, T. Pheby, and A.S. Rice. 2007. Further characterization of a rat model of varicella zoster virus-associated pain: Relationship between mechanical hypersensitivity and anxiety-related behaviour, and the influence of analgesic drugs.Neuroscience144: 1495–1508. ...
Using several preclinical approaches it was shown that the noradrenergic component of tapentadol interacts with the opioid component and that both synergistically contribute to the analgesic effect of the substance. In comparison to known drugs with only one of the two modes of action, tapentadol, des...