Mechanisms of Pain and Analgesic CompoundsRowlingson, John C.Anesthesia & Analgesia
Understanding these mechanisms is essential for effective management, although evidence from preclinical models should be interpreted with caution. A range of pharmacological analgesic and immunomodulatory agents, psychological interventions and surgery may help manage RA pain. Pain contributes importantly to ...
The lack of effective understanding of the pain mechanism of McCune–Albright syndrome (MAS) has made the treatment of pain in this disease a difficult clinical challenge, and new therapeutic targets are urgently needed to address this dilemma. Objective This paper summarizes the novel mechanisms, ...
Understanding the mechanisms of migraine remains challenging as migraine is not a static disorder, and even in its episodic form migraine remains an “evolutive” chronic condition. Considerable progress has been made in elucidating the pathophysiological mechanisms of migraine, associated genetic factors ...
It is known from various analgesics and NSAIDs (non steroidal anti inflammatory drugs) that different mechanisms of their analgesic effect are discussed in the most diverse of pain models (e.g. molar extraction, postoperative postpartum pain, back pain, migraine, and tension-type headache) and ...
Xiong, B.J.; Xu, Y.; Jin, G.L.; Liu, M.; Yang, J.; Yu, C.X. Analgesic effects and pharmacologic mechanisms of the Gelsemium alkaloid koumine on a rat model of postoperative pain. Sci. Rep. 2017, 7, 14269. [CrossRef] [PubMed]...
Objective: To study the analgesic effect and central mechanism of CQ compound in rat models with tibia metastatic cancer pain. Method: Female Wistar rats were randomly divided into sham operation group and surgery group,with operation control and tibia metastatic cancer pain operation for Walker-256...
One of the most prominent pathways in chronic tendon pain is that of the SP:NK1 axis, where both the mediator and receptor are up-regulated. The concept that NK1 receptor blockers would represent a novel class of analgesic drugs, as suggested by the preclinical studies, has however not ...
In the current study, we sought to investigate whether WTD exhibits analgesic effects in a spinal nerve ligation (SNL) model in mice and to reveal the possible underlying molecu- lar mechanisms. Figure 1 illustrates a schematic diagram of our systematic strategies: first, the SNL mouse model ...
Once the patient is receiving a stable dosage of a long-acting medication, an adequate trial of an opioid analgesic requires 4 to 6 weeks to assess both pain and function. Pain reduction without improvement in function indicates a need to consider modifying treatment. With careful titration and ...