The mechanism of action of the non-narcotic analgesics. Med. Clin. North Am. 52 (1), 3 - 14.F. Guzman and R. K. S. Lim , The mechanism of Action of the Non-Narcotic Analgesics , Med. Clin. N. Am. 52 , 3 (1968).Guzman, F., and Lim, R. K. S. (1968). The mechanism...
Botha B, Müller FO, Krueger FGM, Melnitzky H, Vermaak L, Louw L (1969) Quantitative assessment of analgesia conferred by various analgesics, as determined by blocking the intra-arterial bradykinin-evoked pain-response in the rat. Eur J Pharmacol 6:312–321 ArticlePubMedCASGoogle Scholar Boutau...
have shown that oral amitriptyline achieves, at a minimum, good to moderate response in up to 2/3 of patients diagnosed with post-herpetic neuralgia and 3/4 of patients diagnosed with diabetic neuropathic pain, and neurogenic pain syndromes that are frequently unresponsive to narcotic analgesics. ...
Together, we establish an approach to explore individual variations in pain response and identify ventral tegmental area glutamatergic neurons and related downstream circuits as critical targets for resilience to socially transferred allodynia and the development of conceptually innovative analgesics....
analgesics16,17,18. Thus, psychiatric conditions like depression and anxiety; and, environmental, cultural, emotional, and psychological factors influence pain perception by altering the affective state. Moreover, pain itself causes depression and anxiety17,19,20,21, which in turn lowers the pain ...
The effect of the analgesics morphine, trimeperidine, fentanyl, and pentazocine and of the psychostimulant amphetamine on the threshold of pain sensation and on autostimulation of the hypothalamus and septum was studied in rats. Electrical stimulation of positive reinforcement systems of the hypothalamus...
Miranda F, Invernizzi R, Samanin R (1979) Studies on the mechanism of the interaction of narcotic analgesics with brain serotonin. Pharmacol Res Commun t I :455 - 466Miranda F, Invernizzi R, Samanin R (1979) Studies on the mechanism of the interaction of narcotic analgesics with brain ...
Lim RK.doi:10.1111/j.1526-4610.1967.hed0703103.xRobert K. S. LimJohn Wiley & Sons, Ltd.HeadacheLim RK. Sites of action of narcotic and nonnarcotic analgesics: Mechanism of pain and analgesia. Headache 7:103-121, 1967.
The mechanism of this central decrease in the sympathetic tone appears to be different from the mechanism of the reduction induced by clonidine or by narcotic analgesics agents. In fact, piperoxan (1 mg.kg-1 i.v.), an alpha adrenoceptor blocking agent, antagonized or reversed the centrally ...