Reports that the pfmdr1 gene of Plasmodium falciparum confers cellular resistance to antimalarial drugs in yeast cells. Growth inhibition assays; Yeast strain and plasmids; Quantitative mating assay; Expression of Pgh-1 proteins in yeast; Concentration-dependent growth inhibition of JPY201 transformants...
However, drug/drug interactions are critical factors in all therapeutic regimens, the co-administration of MDR modulators with drugs that are MDR1-Pgp substrates needing to be balanced with lower drug concentrations to avoid unpredictable side effects [27]. In this regard, the FDA concept paper ...
Taken together, our findings suggested that overexpression of Runx3 could sensitize gastric cancer cells to chemotherapeutic drugs by downregulating the Bcl-2, MDR-1 and MRP-1. 2005 Wiley-Liss, Inc. 展开 关键词: tumor suppressor gene Runx3 gastric cancer multidrug resistance ...
UHRF1 inhibits MDR1 gene transcription and sensitizes breast cancer cells to anticancer drugs. Breast Cancer Res. Treat. 124, 39-48 (2010).Jin W, Liu Y, Xu SG, Yin WJ, Li JJ, Yang JM and Shao ZM. UHRF1 inhibits MDR1 gene tran- scription and sensitizes breast cancer cells...
UIC2 mAb, thus produced, as well as fragments and recombinant derivatives thereof, may be used to detect and isolate multidrug resistant primate cells and human mdr1 gene products, and to reverse multidrug resistance in primate cells, including cells of multidrug resistant human tumors.MECHETNER, ...
Multidrug resistance of testis carcinomas: detection of P-glycoprotein and MDR1 gene expression and its clinical relevance: 136.An abstract is unavailable. This article is available as a PDF only.NicolaH EBodrogiOláh
Drug resistance often emerges from mutations in solute transporters. Single amino acid exchanges may alter functionality of transporters with ‘de novo’ ability to transport drugs away from their site of action. The PfMDR1 transporter (or P-glycoprotein 1) is located in the membrane of the diges...