A genetic mutation in the MDR1 gene in dogs can have a potentially life-threatening effect on the way your pup responds to common medications. Learn more now.
Norgaard JM, Bukh A, Langkjer ST, Clausen N, Palshof T, Hokland P: MDR1 gene expression and drug resistance of AML cells. Br J Haematol 1998, 100:534-540.Norgaard JM,,Bukh A,Langkjer ST,et al.MDR1 gene expression and drugresistance of AML cells. British Journal of Haematology . ...
Using MDCK-MDR1 cells (a transfected cell line overexpressing human P-glycoprotein (multidrug resistance 1; MDR1)) to evaluate whether your compound is a substrate of the P-glycoprotein (P-gp) efflux transporter is crucial in early drug discovery/development as such knowledge feeds into both: ...
E-mail:ydyxwyb@ 163.com 由多药耐药基因 1(Multi-drug resistance gene1,MDR1)编码的 P 糖蛋白(P-glycoprotein,P-gp)转运 ,其中研究最多的是 MDR1 3435 位点 C->T 突变,其突变结果导致 MDR1 的表达量 和 P-gp 的结构,功能发生明显改变[4-6].目前,已有 Li Y 等[7]报 道了 MDR1 基因多态性...
7、ith acute leukemia.Key words:Leukemia;Drug resistance;Gene expression;Polymerase chain reaction;Prognosis急性白血病(AL)患者的多药耐药(MDR)是导致化疗失败的主要原因。文献报道中多药耐药基因mdr1及多药耐药相关蛋白(MRP)基因的表达均与AL患者的临床耐药密切相关,肺耐药蛋白(LRP)基因是1993年发现的又一多药耐...
Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects Background P-glycoprotein, the gene product of MDR1 , confers multidrug resistance against antineoplastic agents but also plays an important role in the bioavailability of common drugs in med...
MDR1/ABCB1 geneP‐glycoproteinpolymorphismsIntroduction: Hyperprolactinemia, a common adverse effect of antipsychotic drugs, is primarily linked to blockade of dopamine D2 receptors in the pituitary gland. Certain antipsychotic drugs, like for example risperidone and paliperidone, are more likely to ...
Our data thus demonstrate a role for NF-κB in the regulation of the mdr1 gene expression in cancer cells and in drug resistance. This is a preview of subscription content, log in via an institution to check access. Similar content being viewed by others TNFAIP8 promotes AML ...
ii!ultidrug resistance of HepG2 by RNAj-mediated gene silence of MD砒and MIuPl Pan Guangdong+,Zhu Xiaowen,h Wuchang,Xiao Yi,TanⅣing,Liu Qiang,Liu Zhen,Tan Shengqiang. +Department ofHepatobiliary and Pancreatic Surgery.Liuzhou People&Hospital,Liuzhou ...
pylori eradication treatment with a 4-drug regimen of rabeprazole, bismuth, tetracycline, and tinidazole (RBTT) in patients with duodenal ulcers. Methods: The study was conducted at Can Tho University of Medicine and Pharmacy. Gene polymorphisms for CYP2C19 and MDR1 C3435T were detected through ...