in the tumour-suppressor genes BRCA1 or BRCA2, proteins which have an essential role in homologous recombination (HR)-mediated repair of DNA double-strand breaks, have increased risk of developing breast and ovarian cancer but are particularly sensitive to olaparib and similar PARPi drugs (Audeh...
Sakaeda T,Nakamura T,Okumura K.Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs. Pharmacogenomics . 2003Sakaeda T, Nakamura T, Okumura K. Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs [ J ]. ...
(also called MDR1-type P-gps) and that belongs to a phylogenetically highly conserved super- family of ATP-binding cassette (ABC) transport proteins (for a review, see Croop et al, 1989), has been found to be responsible for differences in brain penetration of antide- pressant drugs (...
As a result, cats with MDR1 medication sensitivity can’t clear certain drugs properly. And when those drugs hang around for longer than intended (particularly in the brain), there can be negative consequences. Did you know? This medical complication can also affect dogs. Learn more → Researc...
小细胞肺癌外周血耐药基因MDR-1、PXR的表达及临床意义 摘要 原发性肺癌是最常见的恶性肿瘤之一。Jl市d,细胞癌约占原发性肺癌的15%～20%, 是肺癌中分化最低、恶性度最高的一种类型且生长迅速,可早期发生转移。大多数 患者在确诊时已经发生转移,且失去手术机会。目前对肺小细胞癌的主要治疗方法 是放疗或化疗或...
However, drug/drug interactions are critical factors in all therapeutic regimens, the co-administration of MDR modulators with drugs that are MDR1-Pgp substrates needing to be balanced with lower drug concentrations to avoid unpredictable side effects [27]. In this regard, the FDA concept paper ...
The cells incubated without drugs were set at 100% survival and were used to calculate the concentration of each cytostatic drug lethal to 50% of the cells (IC50). Colony formation assay For evaluation of colony formation, 1000 cells per well were seeded into 6-well plates, followed by ...
Nevertheless, special care has to be taken in dogs with MDR1 mutation. Homozygote dogs completely lack MDR1 function, which makes them highly susceptive to adverse effects by MDR1 substrate drugs [12]. Although MDR1 overexpression appears to be the driving mechanism for doxorubicin resistance in...
Drug resistance often emerges from mutations in solute transporters. Single amino acid exchanges may alter functionality of transporters with ‘de novo’ ability to transport drugs away from their site of action. The PfMDR1 transporter (or P-glycoprotein 1) is located in the membrane of the diges...
Multidrug resistance (MDR) is a kind of acquired resistance of microorganisms and cancer cells to chemotherapic drugs that are characterized by different chemical structure and different mechanism of action. Classic MDR is the consequence of the over-expression of a variety of proteins that extrude ...