MDCK-MDR1细胞药物体外吸收模型的建立及验证
Using MDCK-MDR1 cells (a transfected cell line overexpressing human P-glycoprotein (multidrug resistance 1; MDR1)) to evaluate whether your compound is a substrate of the P-glycoprotein (P-gp) efflux transporter is crucial in early drug discovery/development as such knowledge feeds into both: ...
CAS号: 英文名: MDR1 transfection into canine kidney cells MDCK-MDR1 英文别名: MDR1 transfection into canine kidney cells MDCK-MDR1 中文名: MDR1转染犬肾细胞MDCK-MDR1 中文别名: MDR1转染犬肾细胞MDCK-MDR1 CBNumber: CB48002572 分子式:
(P—gP) expressioninMDCK—MDR1 cells,itcouldbeusedasadrugtransportmodeltoscreenP—gpsubstratesorinh ibitors,aswellasmodels ofintestinalmucosa,bloodbrainbarrierandkidney.Althoughtherearesomed isadvantagesinMDCK— MDR1cellmodel,itisaneffectivetoolforimplementingpermeabilityofdrug inanoptimalfashion. Keywords:...
英文名称 MDR1 transfection into canine kidney cells MDCK-MDR1 英文同义词 MDR1 transfection into canine kidney cells MDCK-MDR1 CAS号 分子式 分子量 0 EINECS号 相关类别 Mol文件 Mol File 结构式 MDR1转染犬肾细胞MDCK-MDR1 性质 MDR1转染犬肾细胞MDCK-MDR1 用途与合成方法 安全信息 MSDS信息 ...
(P-gp)expressioninMDCK-MDR1cells, itcouldbeusedasadrugtransportmodeltoscreenP-gpsubstratesorinhibitors, aswellasmodelsofintestinalmucosa, bloodbrainbarrierandkidney.AlthoughtherearesomedisadvantagesinMDCK-MDR1 cellmodel, itisaneffectivetoolforimplementingpermeabilityofdruginanoptimalfashion.Keywords:MDCK-MDR1 ...
有报道∞引,经转染了人 的稳定,这一作用部分是通过脑微血管内皮细胞 mdrl基因的MDCK细胞内的神经酰胺己三糖苷含 microvascularendothelial (brain cells,BMECs)上 P-gp的外排作用实现的。BBB的体外模型BMECs体,从而使得MDCK—MDRl细胞对细菌外毒素的敏 I astrocytes,TIA)体外共感性增加了1×105—1×106倍。 与I...
Because there is high polarized P-glycoprotein (P-gp) expression in MDCK-MDR1 cells, it could be used as a drug transport model to screen P-gp substrates or inhibitors, as well as models of intestinal mucosa, blood brain barrier and kidney. Although there are some disadvantages in MDCK-...
Because there is high polarized P2glycoprotein ( P2gp) expression in MDCK2 MDR1cells, it could be used as a drug transportmodel to screen P2gp substrates or inhibitors, aswell asmodelsof intestinalmucosa, blood brain barrier and kidney . Although there are some disadvantages in MDCK2MDR1 cell...
The MDCK-MDR1 cells exhibited higher polarized efflux of (3H)-digoxin than did Caco-2 and MDCK-WT cells. KM values of vinblastine in Caco-2, MDCK-WT, and MDCK-MDR1 cells were 89.2 +- 26.1, 24.5 +- 1.1, and 252.8 +- 134.7 muM, respectively, whereas Vmax values were 1.77 +- 0.22...