MDCKII-BCRPandMDCKIIcellmodelswasused.MDCKII-BCRPandMDCKIIcellmonolayermodelwas usedtoinvestigatethebi-directiontransportofsotalol,propranolol,propafenone,procainamideandflecainide. DrugconcentrationsweremeasuredbyHPLC-UVorchemiluminescence.Theapparentpermeabilitycoefficient ...
Key words: fetal tachyarrhythmia; breast cancer resistance protein; MDCKII-BCRP cell; MDCKII cell; transport mechanism; flecainide 乳腺癌耐药蛋白 (breast cancer resistance protein, BCRP 细胞模型系统地探讨这些治疗胎儿快速性心 [1] BCRP) 是 1998 年 Doyle 等 首次从乳腺癌细胞系 律失常的药物 ( ...
Here we used a CRISPR-Cas9 edited Madin-Darby canine kidney (MDCK) II cell line (MDCKcMDR1-KO) for stable expression of human BCRP (hBCRP) with no endogenous canine MDR1 (cMDR1) expression (MDCK-hBCRPcMDR1-KO). Targeted quantitative proteomics verified expression of hBCRP, and global ...
P58 - Utilising a dual human transporter MDCK_MDR1_BCRP cell line to assess efflux at the blood brain barrierdoi:10.1016/j.dmpk.2020.04.059Dermot McGinnityNicola ColcloughRavindra AlluriDanxi LiYumei YanDrug Metabolism and Pharmacokinetics
Evaluation of Drug Transport in MDCKII-Wild Type, MDCKII-MDR1, MDCKII-BCRP and Caco-2 Cell LinesIntroductionPathophysiology of Hepatobiliary SystemInborn Errors of Bile Acid/Salt Transporter DeficienciesDrugs and Cholestatic Liver DiseasePhospholipases and PhospholipidosisMechanisms of Toxicity Associated ...
Genomic knockout of endogenous canine P-glycoprotein in wild-type, human P-glycoprotein and human BCRP trans- fected MDCKII cell lines by zinc finger nucleases. Pharm Res. 2015;32(6): 2060-2071.Gartzke D, Delzer J, Laplanche L, Uchida Y, Hoshi Y, Tachikawa M, Terasaki T, Sydor J, ...
2014. Genomic Knockout of Endogenous Canine P-Glycoprotein in Wild-Type, Human P- Glycoprotein and Human BCRP Transfected MDCKII Cell Lines by Zinc Finger Nucleases. Pharm Res: 1-12.Gartzke D, Delzer J, Laplanche L, et al. Genomic knockout of endogenous canine P-glycoprotein in wild-type...