首先,在正常的MDCK细胞中转染人MRP2 cDNA,构建MRP2过表达的MDCK/MRP2细胞。检测MDCK以及MDCK/MRP2细胞对35种黄酮类化合物(橘皮素、白杨素、木樨草素、牡荆素、异牡荆素、山柰酚、芦丁、槲皮素、漆黄素、柚皮苷、水飞蓟素、黄豆黄素、异...
The aim of the present study was to investigate the ability of non-ionic surfactants to inhibit MRP2-mediated transport in vitro in MDCKII MRP2 cells. Transport studies across MDCKII MRP2 cell monolayers were performed using 3H-etoposide and 3H-digoxin. 19 different non-ionic surfactants, includin...
Multidrug resistance-associated protein 2 is involved in the efflux of Aconitum alkaloids determined by MRP2-MDCKII cells[J].Life sciences 2015.Dai PM,Zhu LJ,Yang XS,et al.Multidrug resistanceassociated protein 2 is involved in the efflux of Aconitum alkaloids determined by MRP2-MDCKII cells[J]...
Fromm. Phase I and II metabolism and MRP2-mediated export of bosentan in a MDCKII-OATP1B1-CYP3A4-UGT1A1-MRP2 quadruple- transfected cell line. Br J Pharmacol. 2013; 169 (1): p. 21-33.Fahrmayr C, Konig J, Auge D, Mieth M, Munch K, Segrestaa J, et al. Phase I and II ...
The aim of the present study was to investigate the ability of non-ionic surfactants to inhibit MRP2-mediated transport in vitro in MDCKII MRP2 cells. Transport studies across MDCKII MRP2 cell monolayers were performed using 3H-etoposide and 3H-digoxin. 19 different non-ionic surfactants, includin...
Establishment and use of new MDCK II cells overexpressing both UGT1A1 and MRP2 to characterize flavonoid metabolism via the glucuronidation pathwayEfflux transportersFlavonoidsGlucuronide"Revolving door"UGTScope: The purpose of this study is to characterize how overexpression of an efflux transporter and ...
Construction and Characterization of Double-Transfected MDCKII cells Stably Expressing Human OAT1 and MRP2Kan Chen
Functional Characterization of a Hepatic Organic Anion Transport Model; OATP1B1 and MRP2 Double Transfected MDCKII cellsKelly Bleasby
Chelerythrine increases glutathione export by the rat multidrug resistant protein MRP2 in madin-darby canine kidney (MDCK) II cellsHelicobacter heilmanniiacute gastric mocosal lesionstouch cytologyA 69-year-old-woman presented with acute epigastric pain, nausea, vomiting and heartburn. Endoscopy ...
Transcellular transport of organic anions across MDCK II monolayers expressing human OATP2 and Mrp2: Makoto Sasaki, Hiroshi Suzuki, Yuichi Sugiyama, University of Tokyo, Tokyo Japandoi:10.1053/S0270-9139(00)83344-3ELSEVIERHepatology