MCM2-7 complex is a novel druggable target for neuroendocrine prostate cancerNeuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer that rarely develops de novo in primary tumors and is commonly acquired during the development of treatment resistance. NEPC is characterized by ...
在真核生物中,负责在复制过程中解开DNA双链的酶最初被康奈尔大学的Bik-Kwoon Tye教授在1983年确定为来自酿酒酵母的小染色体维持蛋白复合物(minichromosome maintenance protein complex, MCM)基因。六个MCM基因--- MCM2至MCM7(MCM2-7)...
2017. Open-ringed structure of the Cdt1-Mcm2-7 complex as a pre- cursor of the MCM double hexamer. Nat Struct Mol Biol 24: 300-308.Zhai Y, Cheng E, Wu H, Li N, Yung PY, Gao N, Tye BK. 2017. Open-ringed structure of the Cdt1-Mcm2-7 complex as a precursor of the MCM ...
在真核生物中,负责在复制过程中解开DNA双链的酶最初被康奈尔大学的Bik-Kwoon Tye教授在1983年确定为来自酿酒酵母的小染色体维持蛋白复合物(minichromosome maintenance protein complex, MCM)基因。六个MCM基因--- MCM2至MCM7(MCM2-7)---的产物形成一种六亚基的环状复合物,作为DNA解链机器---DNA复制螺旋酶---...
Although there is evidence that individual components might have other roles, the essential nature of the MCM2-7 complex in DNA replication has made it difficult to uncover these. Here, we present a detailed analysis of Arabidopsis thaliana mcm2 - 7 mutants and reveal phenotypic differences. The...
在一项新的研究中,来自中国香港大学、香港科技大学、香港理工大学和法国居里研究所的研究人员发现了人类MCM2-7复合物调节复制起始的新机制。这一发现有助于开发一种新的有效的抗癌策略,有可能选择性地杀死癌细胞。相关研究结果发表在2023年1月5日的Cell期刊上,论文标题为“The human pre-replication complex is an ...
在一项新的研究中,来自中国香港大学、香港科技大学、香港理工大学和法国居里研究所的研究人员发现了人类MCM2-7复合物调节复制起始的新机制。这一发现有助于开发一种新的有效抗癌策略,有可能选择性地杀死癌细胞。相关研究结果发表在2023年1月5日的Cell期刊上,论文标题为“The human pre-replication complex is an ope...
The MCM2–7 complex is essential for both the initiation and elongation phases of eukaryotic chromosome replication. There is some evidence that MCM2–7 proteins may act as a DNA helicase; at the same time, a variety of other DNA helicases have also been implicated in the replication of euk...
Seeing is believing: The MCM2–7 helicase trapped in complex with its DNA loaderSeeing is believing: The MCM2–7 helicase trapped in complex with its DNA loaderSaccharomyces cerevisiaeMultiprotein ComplexesDNA-Binding ProteinsSaccharomyces cerevisiae ProteinsChromosomal...
DNA 复制源识别复合物 (origin recognition complex, ORC)首先识别并结合到复制起始位点上,作为预复制复合物组装平台(pre-replication complex, pre-RC)[9]。随后招募Cdc6、Cdt1和MCM2-7蛋白,完成pre-RC组装[10]。真核细胞有丝分裂进入S期后,CDK和DDK蛋白将依次磷酸化激活pre-RC蛋白,活化的pre-RC进一步招募Cdc...