MCM2-7 complex is a novel druggable target for neuroendocrine prostate cancerNeuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer that rarely develops de novo in primary tumors and is commonly acquired during the development of treatment resistance. NEPC is characterized by ...
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during rep...
2017. Open-ringed structure of the Cdt1-Mcm2-7 complex as a pre- cursor of the MCM double hexamer. Nat Struct Mol Biol 24: 300-308.Zhai Y, Cheng E, Wu H, Li N, Yung PY, Gao N, Tye BK. 2017. Open-ringed structure of the Cdt1-Mcm2-7 complex as a precursor of the MCM ...
The MCM2–7 complex is believed to function as the eukaryotic replicative DNA helicase. It is recruited to chromatin by the origin recognition complex (ORC), Cdc6, and Cdt1, and it is activated at the G1/S transition by Cdc45 and the protein kinases Cdc7 and Cdk2. Paradoxically, the ...
在真核生物中,负责在复制过程中解开DNA双链的酶最初被康奈尔大学的Bik-Kwoon Tye教授在1983年确定为来自酿酒酵母的小染色体维持蛋白复合物(minichromosome maintenance protein complex, MCM)基因。六个MCM基因--- MCM2至MCM7(MCM2-7)...
在真核生物中,负责在复制过程中解开DNA双链的酶最初被康奈尔大学的Bik-Kwoon Tye教授在1983年确定为来自酿酒酵母的小染色体维持蛋白复合物(minichromosome maintenance protein complex, MCM)基因。六个MCM基因--- MCM2至MCM7(MCM2-7)---的产物形成一种六亚基的环状复合物,作为DNA解链机器---DNA复制螺旋酶---...
The MINICHROMOSOME MAINTENANCE 2-7 (MCM2-7) complex, a ring-shaped heterohexamer, unwinds the DNA double helix ahead of the other replication machinery. Although there is evidence that individual components might have other roles, the essential nature of the MCM2-7 complex in DNA replication ...
在真核生物中,负责在复制过程中解开DNA双链的酶最初被康奈尔大学的Bik-Kwoon Tye教授在1983年确定为来自酿酒酵母的小染色体维持蛋白复合物(minichromosome maintenance protein complex, MCM)基因。六个MCM基因--- MCM2至MCM7(MCM2-7)---的产物形成一种六亚基的环状复合物,作为DNA解链机器---DNA复制螺旋酶---...
在一项新的研究中,来自中国香港大学、香港科技大学、香港理工大学和法国居里研究所的研究人员发现了人类MCM2-7复合物调节复制起始的新机制。这一发现有助于开发一种新的有效抗癌策略,有可能选择性地杀死癌细胞。相关研究结果发表在2023年1月5日的Cell期刊上,论文标题为“The human pre-replication complex is an ope...
The MCM2–7 complex is essential for both the initiation and elongation phases of eukaryotic chromosome replication. There is some evidence that MCM2–7 proteins may act as a DNA helicase; at the same time, a variety of other DNA helicases have also been implicated in the replication of euk...