在真核生物中,负责在复制过程中解开DNA双链的酶最初被康奈尔大学的Bik-Kwoon Tye教授在1983年确定为来自酿酒酵母的小染色体维持蛋白复合物(minichromosome maintenance protein complex, MCM)基因。六个MCM基因--- MCM2至MCM7(MCM2-7)---的产物形成一种六亚基的环状复合物,作为DNA解链机器---DNA复制螺旋酶---...
在真核生物中,负责在复制过程中解开DNA双链的酶最初被康奈尔大学的Bik-Kwoon Tye教授在1983年确定为来自酿酒酵母的小染色体维持蛋白复合物(minichromosome maintenance protein complex, MCM)基因。六个MCM基因--- MCM2至MCM7(MCM2-7)...
The study further reveals that inhibition of MCM2/3/4/6 complex using ciprofloxacin or other targeted approaches may represent a new effective therapy for NEPC. Our studies warrant further exploration of design and screening for MCM2-7 complex-specific inhibitors....
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during rep...
在真核生物中,负责在复制过程中解开DNA双链的酶最初被康奈尔大学的Bik-Kwoon Tye教授在1983年确定为来自酿酒酵母的小染色体维持蛋白复合物(minichromosome maintenance protein complex, MCM)基因。六个MCM基因--- MCM2至MCM7(MCM2-7)---的产物形成一种六亚基的环状复合物,作为DNA解链机器---DNA复制螺旋酶---...
MCM2-7 complex is a novel druggable target for neuroendocrine prostate cancerEn-Chi Hsu, Michelle Shen, Merve Aslan, Shiqin Liu, Manoj Kumar, Fernando Garcia-Marques, Holly M. Nguyen, Rosalie Nolley, Sharon J. Pitteri, Eva Corey, James D. Brooks & Tanya Stoyanova ...
MCM2-7 bind together to form the heterohexameric MCM complex that is thought to act as a replicative helicase at the DNA replication fork (1-5). This complex is a key component of the pre-replication complex (pre-RC) (reviewed in 1). Cdc6 and CDT1 recruit the MCM complex to the ...
The MCM2-7 complex forms the core of the replicative helicase which acts as the molecular motor that uses ATP binding and hydrolysis to fuel the unwinding of double-stranded DNA at the replication fork in eukaryotes. This complex is the putative replicative helicase essential for 'once per cell...
MCM2-7 bind together to form the heterohexameric MCM complex that is thought to act as a replicative helicase at the DNA replication fork (1-5). This complex is a key component of the pre-replication complex (pre-RC) (reviewed in 1). Cdc6 and CDT1 recruit the MCM complex to the ...
the sub-assembly MCM4/6/7 exhibits the DNA helicase activity [37,38,39,40]. MCM2 which is weakly associated with this sub-complex negatively regulates its helicase activity [36,37]. The strong interaction between MCM3 and MCM5 serves also negative regulatory function on MCM2–7 ATPase acti...