髓细胞白血病基因 - 1(Myeloid cell leukemia gene-1,Mcl - 1)是 Bcl - 2 家族的关键成员,抑制细胞凋亡,参与多种癌症的发生发展。研究团队前期发现,敲低 Mcl - 1 可改变 BCG 刺激下巨噬细胞的极化,这表明 Mcl - 1 下调可能调节巨噬细胞极化,进而影响 BCG 对膀胱癌细胞的作用。此外,c-Jun N 端激酶(c...
Mcl-1 gene promoter insertions do not correlate with disease outcome, stage or VH gene mutation status in chronic lymphocytic leukaemia. Leukemia 2005;19:871-873.Tobin G, Skogsberg A, Thunberg U, Laurell A, Aleskog A, Merup M et al. Mcl-1 gene promoter insertions do not correlate with ...
In addition, conditional disruption of the corresponding mcl-1 gene shows that Mcl-1 plays an important role in early lymphoid development and in the maintenance of mature lymphocytes (13). Kozopas, K.M. et al. (1993) Proc Natl Acad Sci USA 90, 3516-20. Yang, T. et al. (1995) J...
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Entrez-Gene Id: 4170Product Usage Information ApplicationDilution Western Blotting 1:1000 Immunohistochemistry (Paraffin) 1:75 - 1:300 Immunofluorescence (Immunocytochemistry) 1:50 - 1:200 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less...
该基因编码一种抗凋亡蛋白,属于bcl-2家族。选择性剪接导致多个转录变体。最长的基因产物(亚型1)通过抑制细胞凋亡来增强细胞存活,而交替剪接的较短的基因产物(亚型2和亚型3)则促进细胞凋亡并诱导死亡。[由RefSeq提供,2010年10月] This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 ...
货号14-9047-82 CNY3,687.00 下单后预计有货时间 25-Apr-2025 查看价格 批量或定制请求 Application Created with Sketch. 图:1/1 MCL-1 Antibody (14-9047-82) in IHC (P) Immunohistochemistry of formalin-fixed paraffin embedded human tonsil tissue using 5 µg/mL of Anti-Human/Mouse MCL-1 Purif...
¥2080.00元/format:100ul 目录号:IPH1033 库存:现货 规格 产品信息 Catalog No. :IPH1033 Reactivity:Human;Mouse Applications:WB; IF/ICC; ELISA Gene Name:MCL1 Protein Name:Induced myeloid leukemia cell differentiation protein Mcl-1 Human Gene Id:4170 ...
技术支持 货号14-6701-82 CNY3,060.00 下单后预计有货时间 02-May-2025 查看价格 批量或定制请求 说明书 实验方案 技术支持 Application Created with Sketch. 图:1/1 MCL-1 Antibody (14-6701-82) in ICC/IF Immunocytochemistry of fixed and permeabilized MCF-7 cells using 5 µg/mL of Mouse IgG1...
The MCL-1 gene is one of the most frequent focal amplifications in breast cancer, occurring in approximately 30% of cases [8]. High MCL-1 expression has been found to correlate with poor prognosis in mixed breast cancers [9] and de-novo copy number amplification correlates with therapeutic ...