Figure 1: Mechanisms of MCL-1 inhibitor-induced MCL-1 protein upregulation, stability, and induction of apoptosis. Credit:Oncotarget(2023). DOI: 10.18632/oncotarget.28440 A new editorial paper titled "Decoding the mechanism behind MCL-1 inhibitors: A pathway to understanding MCL-1 protein stability...
Understanding whether a common mechanism exists of GOF inhibition for Bcl-x and Mcl-1 anti-apoptotic proteins is critical for design drugs with GOF cytotoxicity. Two-photon confocal fluorescent imaging of Bcl-x- and Mcl-l-over-expressing cells showed mitochondrial hyperpolarization and increase in ...
Each profiling modality will be performed by a different institution included in the NIH Molecular Characterization of Screen-Detected Lesions (MCL) consortium. This pilot study will inform our decision to expand our study to a full-scale review of 200 patients (100 DCIS, 100 invasive cancer) ...
Differential Binding Affinities of Anti-Apoptotic MCL-1 and A1 Proteins for the Pro-Apoptotic BH3 Peptides: Understanding the Molecular Basis using MD Simulationsprotein interactionstransportsedimentationsignal transductionNot Availabledoi:10.1016/j.bpj.2010.12.2351Modi...
A ruptured medial collateral ligament (MCL) can generally heal spontaneously; however, its remodeling process takes years and its biomechanical properties remain inferior when compared to the normal MCL. It is also known that a midsubstance anterior cruciate ligament (ACL) tear has limited healing ...
By a News Reporter-Staff News Editor at Network Daily News - New researchon Networks is the subject of a report. According to news reporting from Changchun, People's Republicof China, by NewsRx journalists, research stated, "Hyperspectral image (HSI) classification is a hot topicin the field...