Methods Mouse colon cancer MC38 cells were transplantedsubcutaneously into 24 C57BL/6J mice, and the changes in body mass and tumor size of mice were recordedonce a week after tumor-bearing, The levels of tumor-infiltrating immune cells, including CD45 + T cells,CD3 + T cells, CD8 + T ...
the transporter, and increase the sensitivity of tumor cells to oxaliplatin.#Astragalus-zedoary exhibits an enhanced antitumor effect and can play a synergistic role with oxaliplatin chemotherapy, thereby significantly enhancing the long-term survival rate and quality of life of tumor-bearing mice.Lei...
Methods Mouse colon cancer MC38 cells were transplanted subcutaneously into 24 C57BL/6J mice, and the changes in body mass and tumor size of mice were recorded once a week after tumor-bearing, The levels of tumor-infiltrating immune cells, including CD45+ T cells, CD3+ T cells, CD8+ T ...
Methods Mouse colon cancer MC38 cells were transplanted subcutaneously into 24 C57BL/6J mice, and the changes in body mass and tumor size of mice were recorded once a week after tumor-bearing, The levels of tumor-infiltrating immune cells, including CD45+ T cells, CD3+ T cells, CD8+ T ...
We have also confirmed that an anti-human CD47 antibody (Hu5F9-hIgG4) can bind to human CD47 expressed on hCD47-MC38 HuCELL tumor cells. Finally, we demonstrated robust antitumor effects of an anti-human CD47 antibody by treating the HuGEMM mice bearing hCD47-MC38 tumors with Hu5F9 ...
To evaluate the effect of immunotherapies, mice bearing established tumors were administered various checkpoint inhibitors or costimulatory antibodies. The costimulatory antibodies anti-GITR, anti-CD137 and anti-OX40 showed no evident anti-tumor effect. In contrast, anti-PD-L1 and anti-PD-1 ...
Methods Mouse colon cancer MC38 cells were transplanted subcutaneously into 24 C57BL/6J mice, and the changes in body mass and tumor size of mice were recorded once a week after tumor-bearing, The levels of tumor-infiltrating immune cells, including CD45+ T cells, CD3+ T cells, CD8+ T ...