EGFR/PI3K/Akt signalling pathway ; Zilongjin Tablets ; icotinib ; Lewis tumor-bearing mice ; antitumor [Abstract] Objective To investigate the mechanism of tumour-suppressive effect and apoptosis of Zilongjin Tablets combined with icotinib through epidermal growth factor receptor (EGFR)/phosphatidylinosito...
The purpose of the current study was to investigate the effect of the dosing time on the pharmacokinetics of erlotinib and the circadian rhythms of the metabolism enzymes in tumor-bearing mice. Female C57BL mice were randomly assigned to six groups. Erlotinib was orally administrated to the mice...
Effects of Yupingfeng granules on tumor metastasis of Lewis tumor -bearing mice by adjusting the EMT LIN Yingxue 1，CUI Haipeng 2，WANG Lingdi 1，YANG Changshuo 3，ZHUANG Pengwei 3（1. Dept. of Pharmacy ，the Affiliated Hospital of Chengde Medical University ，Hebei Chengde 067000...
Organism TypeMouseATCC# CLR1642: Cell line established from the lung of a C57BL mouse bearing a tumor resulting from an implantation of primary Lewis lung carcinoma. The cells are resistant to 1,3-bis-(2-chloroethyl)-1-nitrosourea, but are sensitive to methotrexate. The cells are reported to...
Organism Type Mouse ATCC# CLR1642: Cell line established from the lung of a C57BL mouse bearing a tumor resulting from an implantation of primary Lewis lung carcinoma. The cells are resistant to 1,3-bis-(2-chloroethyl)-1-nitrosourea, but are sensitive to methotrexate. The cells are report...
When administered to Lewis lung cancer (LLC) tumor-bearing mice, 5c significantly inhibited IDO-1 activity and suppressed tumor growth. In addition, 5c reduced the numbers of Foxp3+ regulatory T cells (Tregs), which are known to prevent the development of efficient antitumor immune responses. ...
tumordoi:10.1002/jlb.42.6.682M. Rita YoungRoger A. EndicottG. Patrick DuffieH. Terry WepsicJohn Wiley & Sons, LtdJournal of Leukocyte BiologyYoung, M. R., R. A. Endicott, G. P. Duffie, and H. T. Wepsic. 1987. Suppressor alveolar macrophages in mice bearing metastatic Lewis lung ...
3Lewis lung tumor-bearing C57Bl/6 mice were treated with 0.625 to 40 mg Il-mofosine/kg per dayp.o. either from days 1 to 9 or from days 11 to 28 after intrafoot-pad tumor cell inoculation. Ilmofosine caused a significant dose-related response on tumor growth and metastases, expressed...
is a cell line established from the lung of aC57BL mouse bearing a tumorresulting froman ...
Pharmacodynamicsofpaclitaxel10ng-circulatingthermosensitiveliposomesinLewistumor-bearingmice LIMei—bo,GUSheng-jiu,ZHAOWen-peng,ZHUKai—mei.GuilinMedwdUn&e~ity,Guilin541004,China Correspondingauthor:ZHUKai—met E—maiZ:glzkm@163.corn 【Abstract】ObjectiveToinvestigatethetumorinhibitionefectofpaclitaxellong·ci...