tailedt-tests (B,D, andF) and two-way ANOVA (C) were used.***p < 0.001,**p < 0.01,*p < 0.05. Not significant (p > 0.05). Thx Thymectomy; siLP Small intestinal lamina propria; MCPT-1 Mast cell protease-1. Full size image We additionally tested the effect of ...
Mast cell tryptase has several unique features, with perhaps the most remarkable being its organization into a tetrameric state with all of the active sites oriented towards a narrow central pore and its consequent complete resistance towards endogenous macromolecular protease inhibitors. Much effort has...
cells to the site of infection and to draining lymph nodes. Interestingly, the character and timing of these responses can vary depending on the type of pathogen stimulus, location of pathogen recognition and sensitization state of the responding mast cells. Recent studies using mast cell activators...
PBdMC were positive for tryptase, which is the main mast cell protease released during degranulation [30] (Fig. 1a). Transmission electron microscopy (TEM) showed mature PBdMC containing secretory vesicles (granules) (Fig. 1b), characteristic for mast cells. Although, many of the granules were...
a protease stored in mastcell granules, may be elevated above the patient's baseline level in the serum or plasma if measured within 3 hours after the onset of the episode in patients with suspected mast cell degranulation or anaphylaxis, regardless of the cause.Angioedema, hives, andwheezingare...
Regulation of rat mast cell protease 1 activity. Rat mast cell protease 1 (RMCP-1) is a chymotrypsin-like serine protease (chymase) that is specifically expressed by connective-tissue-type mast cells. It ... Pejler,Gunnar,Berg,... - 《European Journal of Biochemistry》 被引量: 47发表: ...
L. Transcriptional regulation of the mucosal mast cell-specific protease gene, MMCP-2, by interleukin 10 and interleukin 3. J. Biol. Chem. 267, 8473–8477 (1992). CAS PubMed Google Scholar Toru, H. et al. Interleukin-4 promotes the development of tryptase and chymase double-positive ...
Mast cells have been linked to osteoporosis and bone fractures, and in a previous study we found that mice lacking a major mast cell protease, chymase, develop increased diaphyseal bone mass. These findings introduce the possibility that mast cell chymase can regulate bone formation, but the und...
Mast cells contribute to the pathology of allergic and other disorders. Strategies to interfere with harmful mast cell-related activities are therefore warranted. Previously we established a principle for inducing selective apoptosis of mast cells, by th
In humans, two common mast cell phenotypes are recognised based on their protease content: mast cells which cinonthtaeinsktirnypatnadsecoonnlnye(cMtiCveT)t,isasnude,maansdt caerlelsaclsoontfaoiunnindgibnostihgntriyfipctaanstenaunmd cbheyrsmianseai(rMwCayTCs)u1b8.mMuCcoTCsaplrteidssoumesin18...