MAST CELL DEGRANULATION INHIBITORPROBLEM TO BE SOLVED: To provide a novel inhibitor for the degranulation of a mast cell.SATO HIDETSUGU佐 藤 秀 次GOTO TAKESHI後 藤 武OMORI NAOYA大 森 直 哉SHIMADA YAYOI島 田 弥 生KO TAKAMASA江 貴 真
Fig. 2. Process of mast cell degranulation and cytokines production via various receptors. AA-Arachidonic acid; cAMP-Cyclic adenosine monophosphate; CRTH2-Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells; CXCR-Cytokine receptor; ERK-Extracellular signal-regulated kinases; GAMs-Granule-as...
4.2.3Mast cell degranulation peptide (MCD) Is abee venomcomponent and, likeapamin, is a neurotoxin but with two sites for interaction in the mammalian body, thebrainand the mast cells. In the brain,MCDbinds to voltage-dependentpotassium channels(Kondo et al., 1992,), increasing the firing r...
Mast cells are critical effectors of allergic inflammation and protection against parasitic infections. We previously demonstrated that transcription factors GATA2 and MITF are the mast cell lineage-determining factors. However, it is unclear whether the
[2].Banks BE, et al. Anti-inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) andcompound 48/80 results from mast cell degranulation in vivo. Br J Pharmacol. 1990 Feb;99(2):350-4. Mast Cell Degranulating (MCD) Peptide物理化学性质 ...
Mast cells are key mediators of cutaneous and mucosal allergies, which are triggered via IgE-FcεR1 signaling. Binding of an allergen to IgE triggers mast cell degranulation, with symptoms ranging from mild to severe systemic anaphylaxis. Mast cells are ...
Demeure, C. E. et al.Anophelesmosquito bites activate cutaneous mast cells leading to a local inflammatory response and lymph node hyperplasia.J. Immunol.174, 3932–3940 (2005).This study shows how mosquito bites can trigger dermal mast cell degranulation and how this can affect the recruitment...
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Activation of TRPV2 allows Ca(2+) ions to enter the cell, which in turn will induce degranulation. We, therefore, suggest that TRPV2 plays a key role in mast-cell degranulation in response to mechanical, heat and red laser-light stimulation. 展开 关键词: Mast cell Degranulation TRPV ...
Mast cell degranulation refers to the process in which mast cells release inflammatory substances, such as histamine, TNF-α, and tryptase, into the circulation upon activation. This process plays a crucial role in immediate hypersensitivity reactions and has been proposed as a pathophysiological mechan...