The effect of ruxolitinib on mast cell degranulation (via measurement of 尾-hexosaminidase, histamine release and CD63 membrane expression) and IL-6, IL-13, MCP-1 and TNF-伪 production was investigated. The involvement of STAT5 activation was explored using the selective STAT5 inhibitor pimozide...
Granulosomes are novel complexes that feature an unexpected partnership between the tetraspanin CD63 and the inflammasome proteins NLRP3 and ASC. Granulosomes assemble on mast cell granules to propel them along microtubules to the plasma membrane for degranulation. This is a preview of subscription ...
Fig. 2.Process of mast cell degranulation and cytokines production via various receptors. AA-Arachidonic acid; cAMP-Cyclic adenosine monophosphate; CRTH2-Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells; CXCR-Cytokine receptor; ERK-Extracellular signal-regulated kinases; GAMs-Granule-asso...
Mast cell degranulation and bradykinin-induced angioedema—searching for the missing link. Front Immunol. 2024;15:1399459. Article CAS PubMed PubMed Central Google Scholar Thapaliya M, Chompunud NAC, Amponnawarat A, Roy S, Ali H. Mast cell-specific MRGPRX2: a key modulator of neuro-immune...
This molecule plays several physiological roles including inhibition of degranulation in several mast cell subtypes [54]. Recently, a novel way of regulating mast cells by CD30l (ligand) has been discovered by Nilsson and coworkers [55]. CD30l is a TNF family member and Nilsson and co...
all while maintaining cell membrane integrity [84,85]. During pancreatitis, mast cells accumulate in the inflammatory fibrotic areas of the pancreas and in the surviving acinar tissue, accelerating inflammatory invasion and pancreatic tissue remodeling by degranulation and release of inflammatory mediators ...
1e). Cytometric analysis of palbociclib-treated BLCs showed dose-dependent inhibition of the upregulation of the expression of the mast cell activation marker CD63 (Fig. 1d). Fig. 1 Palbociclib attenuation of mast cell degranulation. a Cell viability of B LCs following DNP-HSA challenge with ...
mast cell as an important initiator of human inflammation, with potential for both beneficial and destructive roles in the development of systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). Regulation and control of mast cell function and of the numerous ...
Of interest, treatment with the mast cell degranulation inhibitor disodium cromoglycate significantly delayed the onset of diabetes (from 63 ± 6 to 82 ± 30 days, p = 0.045), with 25% of the animals remaining diabetes-free until the end of the study (130 days). Overall, disodium cro...
The present disclosure provides methods for the treatment of mast cell gastritis, mast cell esophagitis, mast cell colitis, mast cell enteritis, mast cell duodenitis, and/or mast cell gastroenteritis. In particular, the present disclosure provides methods for the treatment of mast cell gastritis, mas...