The MAPK pathway was activated in cells resistant to epirubicin; MAPK inhibition ameliorated epirubicin resistance. In triple-negative breast cancer (TNBC), progestin and adipoQ receptor 3 (PAQR3) were the most significantly decreased negative MAPK regulators. PAQR3 increased epirubicin sensitivity and ...
Historical events of the discovery and development of the RAS/RAF/MAPK pathway in health and diseases. The journey of the MAPK signal cascade commenced in 1960s with the groundbreaking discovery of the viralRASgene. Subsequently, in 1992, the identification of RAF as both an upstream kinase acti...
About 15–20% of breast cancer (BCa) is triple-negative BCa (TNBC), a devastating disease with limited therapeutic options. Aberrations in the PI3K/PTEN signaling pathway are common in TNBC. However, the therapeutic impact of PI3K inhibitors in TNBC has
Targeted inhibition with an NRP1 monoclonal antibody reduced spheroid-forming capacity and potently suppressed tumor growth in an orthotopic claudin-low TNBC xenograft model. Finally, we show that NRP1 acts as a central hub for the aberrant activation of the RAS-MAPK pathway via EGFR and PDGFR ...
2C), including Src family and some kinases of MAPK signaling pathway. The top 20 genes of top 5 GO pathways of pY/pS/pT peptides in patients with breast cancer were listed in Figs. S5–7. And proteins enriched in top 5 KEGG pathways were shown in Figs. S8–13. Fig. 2 Significant...
Capsaicin-induced apoptosis in the human glioblastoma U87MG cells via p-38 MAPK and Bcl-2/Bax signaling pathway Han IH, Choi BK, Cha SH and Cho WH: Capsaicin-induced apoptosis in the human glioblastoma U87MG cells via p-38 MAPK and Bcl-2/Bax signaling pathway... HJ Jin,YJ Choi,IH Ha...
Yes-associated protein 1 promotes papillary thyroid cancer cell proliferation by activating the ERK/MAPK signaling pathway Yes-associated protein 1 (YAP1) stimulates cell proliferation, epithelial-to-mesenchymal transition, invasion and metastasis in several cancers. Here, we i... L Tian,D Wen,B Ma...
To validate the RPPA data showing potential PI3K and MAPK pathway inhibition by miR-564, we examined AKT and ERK1/2 phosphorylation levels in miR-564 transfected MDA-MB-231 and MCF-7 cells, which represent triple negative breast cancer (TNBC) and estrogen receptor positive (ER+) breast cancer...
8 Overexpression of p-Akt(Ser473) can be detected in 78% of luminal-like breast cancer, in 80% of HER2-positive breast cancer and in 58–62% of TNBC cases.9 The MAPK pathway is less frequently altered in breast cancer. Mutations in genes encoding this pathway range from 2 to 10%.10...
Kenjiro Imada [39] et al. found that YBX1 interacts with RAF1 and regulates its expression through proteasomal pathway. We exhibited that YBX1 can also bind to RAF1 and regulate the MAPK singling pathway in TNBC. Otherwise, YBX1 can revert the negative effects of piR-YBX1 via the MAPK ...