Phosphorylation of MAP kinases is important for proper translation of T cell antigen receptor (TCR) signals into thymocyte cell fates, but the role of MAP kinase phosphatase (MKP) activity in thymocyte development has not been characterized. To explore the role of MKP in thymocytes, we ...
Dual-specificity MAP kinase phosphatases (MKPs) and cancer There are ten mitogen-activated protein kinase (MAPK) phosphatases (MKPs) that act as negative regulators of MAPK activity in mammalian cells and these can... Stephen,M.,Keyse - 《Cancer & Metastasis Reviews》 被引量: 614发表: 2008...
J. (1999). Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal protein kinase activity. Journal of ...
R. et al. Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal protein kinase activity. J. Biol. ...
This neuroprotective effect of MKP-1 was demonstrated to be dependent on its enzymatic activity, being ablated by mutation of its phosphatase domain and being attributed to inhibition of specific MAP kinases (MAPKs). Overexpression of MKP-1 prevented the polyglutamine-expanded huntingtin-induced ...
英文名 MAP kinase phosphatase 2 英文别名 MAP kinase phosphatase 2Anti-DUSP4 antibody produced in rabbitDual specificity protein phosphatase hVH2Mitogen-activated protein kinase phosphatase 2MKP-2 存储条件 -20°C 您刚刚浏览过 MAP kinase phosphatase 2 刚刚更新的化工产品 65989-27-7 66003-73-4 ...
Mitogen-activated protein kinase phosphatases (MKPs) play key roles in inflammation and immune mediated diseases. Here we investigated the mechanisms by which MKP-2 modulates central nervous system (CNS) inflammation in experimental autoimmune encephalomyelitis (EAE). Our results show that MKP-2 mRNA ...
amino acid sequenceand ability to phosphorylate in vitro similar substrates. Maximal MAP kinase activity requires that bothtyrosineand threonine residues are phosphorylated. This indicates that MAP kinases act as switch kinase that transmits information of increased intracellulartyrosine phosphorylationto ...
The abnormal regulation or activity of MAPK signalling pathways has been implicated as a key event in the initiation and progression of many human cancers. Furthermore, MAPK signalling also plays a key role in the cellular response to many... 关键词: MAP kinase DUSP MAP kinase phosphatase ...
Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance. Insulin resistance, a hallmark of type 2 diabetes and obesity, is associated with increased activity of MAP and stress-activated protein (SAP) kinases, whi... Emanuelli,Brice,Eberlé,...