The cAMP/protein kinase A (PKA) pathway is known to be the major biochemical pathway for mu opioid receptor signaling. However, our data showed that stimulating adenylyl cyclase or activating PKA had no effect o
Maximal MAP kinase activity requires that both tyrosine and threonine residues are phosphorylated. This indicates that MAP kinases act as switch kinase that transmits information of increased intracellular tyrosine phosphorylation to that of serine/threonine phosphorylation [68–70]. Although MAP kinase...
R. et al. Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal protein kinase activity. J. Biol. ...
Modulation of behavioural responses by neuronal signalling pathways remains incompletely understood. Signalling via mitogen-activated protein (MAP) kinase cascades regulates multiple neuronal functions. Here, we show that neuronal p38α, a MAP kinase of the p38 kinase family, has a critical and specific...
(1993). Stimulation of tyrosine phosphorylation and mitogen-activated-protein (MAP) kinase activity in human SH-SY5Y neuroblastoma cells by carbachol. Biochem... S Offermanns,E Bombien,G Schultz - 《Biochemical Journal》 被引量: 117发表: 1993年 p38 Map Kinase Mediates Bax Translocation in Nitric...
This is consistent with the finding that stimuli that trigger LTP in the hippocampus can induce MAP kinase activity (Thomas et al. 1994), and raises the possibility that PKA is important for the activation of MAP kinase, which could in turn mediate events that are critical for the ...
At both time points, MAP kinase activity declined by about 50% after 30 minutes (data not shown). Stimulation of PAE cells with serum, or Swiss 3T3 cells with PDGF, induced an activation of p42mapk that was sustained for at least 2 hours (Figure 3a and Figure 3c), although in ...
Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins... M David,E Petricoin,C Benjamin...
The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups, the p38 group of MAP kinases, serve as a nexus for signal transduction a
MAP kinase activity (p42-ERK1/p44-ERK2) was determined by in vitro assay. In each case, values reflect the mean ±SE of duplicate determinations, and are expressed as a percentage of basal activity present in untreated controls. Data shown are from a representative study performed three ...