MAP kinase kinase kinases and innate immunity. Trends Immunol. 27:40-48.Symons A, Beinke S, Ley SC (2006) MAP kinase kinase kinases and innate immunity. Trends Immunol 27(1): 40‐48Symons, A., Beinke, S. and Ley, S. C. (2006) MAP kinase ...
composed of a MAP kinase, aMAP kinase kinase, and aMAP kinase kinase kinase. Phosphorylation and activation of MAP kinases byMAP kinase kinasesoccurs on two residues within atripeptidemotif (Thr-Xaa-Tyr) located within the T loop that controls the conformation of the MAP kinase active site...
MAP KINASE KINASE KINASE KINASE 3 (MAP4K3) AS A BIOMARKER AND THERAPETIC TARGET FOR AUTOIMMUNE DISEASE, CANCER, INFLAMMATION AND IL-17-ASSOCIATED DISEASE Methods for identifying a therapeutic agent for treating a Germinal Center Kinase (GCK)-Like Kinase (GLK)-mediated disease are disclosed. Metho...
Here we have identified a novel MAP kinase kinase kinase (MAPKKK), termed MLTK (for MLK-like mitogen-activated protein triple kinase), whose expression is increased by activation of the ERK/MAPK pathway. There are two alternatively spliced forms of MLTK, MLTKα and MLTKβ. When overexpressed ...
Abiotic stresses, including drought and salinity, trigger a complex osmotic-stress and abscisic acid (ABA) signal transduction network. The core ABA signalling components are snf1-related protein kinase2s (SnRK2s), which are activated by ABA-triggered in
Elevated ERK-MAP kinase activity protects the FOS family member FRA-1 against proteasomal degradation in colon carcinoma cells The AP-1 (activator protein-1) complex, which consists of proteins of the Fos and Jun families, is thought to play an important role in the balance between... Chris ...
an IκB kinase-regulated MAP kinase kinase kinase Thorsten Gantke1, Srividya Sriskantharajah1, Steven C Ley1 1Division of Immune Cell Biology, National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK The IκB kinase (IKK) complex plays a well-documented role in innate and...
The Hippo pathway plays a central role in tissue homoeostasis, and its dysregulation contributes to tumorigenesis. Core components of the Hippo pathway include a kinase cascade of MST1/2 and LATS1/2 and the transcription co-activators YAP/TAZ. In response to stimulation, LATS1/2 phosphorylate ...
Kinase activity MAP kinase-interacting kinase 1 Translation regulation 1. Introduction The MAP kinase interacting kinases (Mnks) belong to the Ca2+/calmodulin-dependent kinase family (CaMK), in particular to kinase group F [1], although, like other CaMK group members, they are not regulated by ...
Modulation of behavioural responses by neuronal signalling pathways remains incompletely understood. Signalling via mitogen-activated protein (MAP) kinase cascades regulates multiple neuronal functions. Here, we show that neuronal p38α, a MAP kinase of