Introduction: The mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs) are switched on by the oncogenic MAPK (ERK) signalling pathway. They phosphorylate eukaryotic initiation factor (eIF) 4E, a protein which recruits ribosomes to mRNAs and thereby mediates their translation. Importantly...
英文名: MAP kinase-interacting protein kinases (MKNK1 and MKNK2) 英文别名: MAP kinase-interacting protein kinases (MKNK1 and MKNK2) 中文名: MAP激酶相互作用的蛋白激酶(MKNK1和MKNK2) 中文别名: MAP激酶相互作用的蛋白激酶(MKNK1和MKNK2)
Kinase activity MAP kinase-interacting kinase 1 Translation regulation 1. Introduction The MAP kinase interacting kinases (Mnks) belong to the Ca2+/calmodulin-dependent kinase family (CaMK), in particular to kinase group F [1], although, like other CaMK group members, they are not regulated by ...
Y. 1998. The expression pattern of the gene for NPK1 protein kinase related to mitogen-activated protein kinases kinase kinase (MAPKKK) in a tobacco plant: correlation with cell proliferation. Plant Cell Physiol. 39: 690–700.
1. Discovery of the MAP kinase Building on evidence that insulin and mitogens acted through novel, possibly covergent mechanisms to promote intracellular protein phosphorylation [1], [2] through the activation of protein (Ser/Thr) kinases [3], [4], Sturgill and Ray [5] detected an insulin-...
The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding The MAP kinase-interacting kinases (Mnk1 and Mnk2) Xie,Jianling,Jenei,... - 《Biochemical Journal》 被引量: 0发表: 2015年 IL-22 is increased in active Crohn's disease and promotes ...
然而,丝裂原活化的蛋白激酶激酶激酶激酶(MAP4Ks)几乎没有被探索【However, MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASEs (MAP4Ks) are hardly explored.】。在这里,我们将全面概述植物 MAP4K 的已知情况,并重点介绍与植...
[155]. PLX-4720 interacts with receptor-interacting serine/threonine-protein kinase 1 (RIPK1) during SARS-CoV-2 infection [153]. RIPK1 is activated by nsp12 and regulates the expression of ACE2 to promote viral transmission. SARS-CoV-2 enters the human body via the ACE2 receptor, and ...
ERK1/2 proteins phosphorylate and regulate hundreds of different proteins including otherprotein kinases, such asribosomal S6 kinases, MAP kinase-activated protein kinases, and MAP kinase-interacting kinases, which in turn regulate gene expression andprotein translation. Following activation, some ERK1/2...
2, 8 Kinases are a family of intracellular signaling regulators that have become therapeutic targets for diverse diseases and kinase inhibitors are in clinical use mainly in the oncology and immune regulation fields.9 Among kinases, mitogen-activated protein kinase kinase kinases (MAP3K) are of ...