( 1992 ) The structure, role, and regulation of Type 1 protein phosphatases , Crit. Rev. Biochem. Mol. Biol. 27 , 227 – 281 .Bollen, M., and W. Stalmans, 1992 The structure, role and regula- tion of type 1 protein phosphatases. Crit. Rev. Biochem. Biol. 27: 227-281....
A variety of scaffold proteins including KSR1/2, IQGAP1, MP1, β-Arrestin1/2 participate in the regulation of the ERK1/2 MAP kinase cascade. The regulatory dephosphorylation of ERK1/2 is mediated by protein-tyrosine specific phosphatases, protein-serine/threonine phosphatases, and dual ...
The mitogen-activated protein kinase (MAPK) p38α is a key regulator in many cellular processes, whose activity is tightly regulated by upstream kinases, phosphatases and other regulators. Transforming growth factor-β activated kinase 1 (TAK1) is an upstream kinase in p38α signaling, and its f...
Members of the BAR domain protein superfamily are essential elements of cellular traffic. Endophilins are among the best studied BAR domain proteins. They
Inhibition of gap-junctional intercellular communication and activation of MAPKs by cyanobacterial extracts the involvement of cyanobacteria toxins in the regulation of GJIC and MAPK, and also that tumor promoting metabolites other than microcystins are present... O Adamovský,L Bláha,P Babica,......
K. A structure is worth a thousand words: new insights for RAS and RAF regulation. Cancer Discov. 12, 899–912 (2022). Tran, T. H. et al. KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat. Commun. 12, 1176...
Results PEA-15 uses a minimal inverted D-peptide binding Structure of the PEA-15–ERK2 complex. To obtain insight into mode. Closer examination of the interaction between the the mechanism underlying ERK1/2 regulation by PEA-15, we C-terminal segment of PEA-15 (residues 122–127) and the...
Normally, epha2 becomes phosphorylated and subsequently degraded and this phosphorylated process is important for normal signaling pathway such as MAPK and Akt. In cancer cells, EphA2 fails to efficiently interact with its ligand on adjacent cells, leading to the accumulation of the un-phosphorylated...
Abstract Mitogen-activated protein kinases (MAPKs) are evolutionarily conserved signaling proteins involved in the regulation of most eukaryotic cellular processes. They are downstream components of essential signal transduction pathways activated by the external stimuli, in which the signal is conveyed throu...
Crystallography and mutagenesis analyses of MAPKs and MAPK-substrate complexes have revealed the mechanism by which MAPKs and their substrates interact. The structures of mammalian and yeast MAPKs have been studied2. Several structural elements within MAPKs that participated in the regulation of kinase...