Malonyl-CoA is a central metabolite across living organisms, serving as the common precursor for fatty acids and their derivatives, including hydrocarbons and fatty acid methyl and ethyl esters, as well as various natural products such as polyketides (for example, the red food colorant carminic ...
Paralleling its role in promoting energy expenditure through FA disposal, PPAR[alpha] also inhibits the lipogenic pathway by induction of the malonyl-CoA decarboxylase which degrades malonyl-CoA, a precursor of FA biosynthesis and inhibitor of the mitochondrial transporter CPT-1 [31] (Figure 1). ...
Use of Malonyl CoA Malonyl CoA is a substrate for fatty acid biosynthesis and an inhibitor of fatty acid oxidation. Malonyl CoA is also a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1[1][2]. Properties Spectrum ...
Malonyl CoA serves as a substrate in fatty acid biosynthesis while inhibiting fatty acid oxidation. It also acts as a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1 [1] [2]. 化学信息 分子量853.58 分子式C24H38N7O19P3S ...
Enzymatic platforms for producing malonyl-CoA-based extender units required for polyketide biosynthesis are often based on malonyl-CoA ligases such as MatB from Rhizobium trifolii and Rhodopseudomonas palustris. However, despite broad interest in the fluorination of polyketides and prior success with engine...
The biosensor was successfully applied as a high-throughput screening tool for identifying targets at a genome-wide scale that could be critical for improving the malonyl-CoA biosynthesis in vivo. The mutant strains selected synthesized significantly higher titers of the type III polyketide triacetic ...
•Activity imbalance of MCR-N and MCR-C caused low 3HP yield of malonyl-CoA route.•Genetic selection system was designed to enrich active MCR-C mutants.•MCR-C activity was increased 5.5-fold by directed evolution.•Lowering MCR-N protein level increased 3HP titer significantly.•Best...
The cessation of phospholipid biosynthesis by the in-hibition of the -glycerol-3-phosphate acyltransferase using a mutant led to an accumulation of long chain acyl-acyl carrier proteins (acyl-ACP) and the concomitant inhibition of fatty acid biosynthesis in . Malonyl-CoA did not accumulate when ph...
Fatty Acid BiosynthesisMetabolic Primary Hyperoxaluria II, PH2Disease Not Available Interactions Drug Interactions This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence...
Malonyl-CoA FapR Biosensors Fatty acid biosynthesis Synthetic biology Genetic circuits Dynamic regulation 1. Introduction The field of metabolic engineering has witnessed rapid advancements, further consolidating it as an enabling technology for engineering biological cell factories for producing value-added ch...