Malonyl-CoA is a central metabolite across living organisms, serving as the common precursor for fatty acids and their derivatives, including hydrocarbons and fatty acid methyl and ethyl esters, as well as various natural products such as polyketides (for example, the red food colorant carminic ...
Paralleling its role in promoting energy expenditure through FA disposal, PPAR[alpha] also inhibits the lipogenic pathway by induction of the malonyl-CoA decarboxylase which degrades malonyl-CoA, a precursor of FA biosynthesis and inhibitor of the mitochondrial transporter CPT-1 [31] (Figure 1). ...
Malonyl-CoAis a precursor metabolite for fatty acidbiosynthesis. • Biosensors allowin situmonitoring of malonyl-CoA intracellular concentration. • Each malonyl-CoA biosensor comprises of arepressorand a reporter module. • The modules can be tuned to improve the biosensor performance. ...
Malonyl CoA serves as a substrate in fatty acid biosynthesis while inhibiting fatty acid oxidation. It also acts as a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1 [1] [2]. 化学信息 分子量853.58 分子式C24H38N7O19P3S ...
Enzymatic platforms for producing malonyl-CoA-based extender units required for polyketide biosynthesis are often based on malonyl-CoA ligases such as MatB from Rhizobium trifolii and Rhodopseudomonas palustris. However, despite broad interest in the fluorination of polyketides and prior success with engine...
The biosensor was successfully applied as a high-throughput screening tool for identifying targets at a genome-wide scale that could be critical for improving the malonyl-CoA biosynthesis in vivo. The mutant strains selected synthesized significantly higher titers of the type III polyketide triacetic ...
The cessation of phospholipid biosynthesis by the in-hibition of the -glycerol-3-phosphate acyltransferase using a mutant led to an accumulation of long chain acyl-acyl carrier proteins (acyl-ACP) and the concomitant inhibition of fatty acid biosynthesis in . Malonyl-CoA did not accumulate when ph...
The first elongation step of fatty acid biosynthesis by a type II dissociated fatty acid synthases is catalyzed by 3-ketoacyl-acyl carrier protein (ACP) sy... Y Li,G Florova,KA Reynolds - 《Journal of Bacteriology》 被引量: 77发表: 2005年 Structural and functional studies of SCO1815 : ...
The upper level of the control system ensures downregulation of endogenous use of malonyl-CoA for fatty acid biosynthesis, which results in accumulation of this pathway intermediate. The lower level of the control system is based on use of a novel biosensor for malonyl-CoA to activate expression ...
Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis. Biosynthesis of the enediyne natural product dynemicin in Micromonospora chersina is initiated by DynE8, a highly reducing iterative type I polyketide synt... Chong,Wai,Liew,... - 《Journal...