12, 13 Given that 4 and 5 are fluorinated at positions associated with the substitution of malonic building blocks, producing these compounds utilizing a biosynthetic approach may represent a sustainable route to produce designer drugs. While malonyl-CoA ligases like MatB represent exciting ...
Efficient production of (2S)-flavanones by Escherichia coli containing an artificial biosynthetic gene cluster Appl. Microbiol. Biotechnol., 68 (2005), pp. 498-504 CrossrefView in ScopusGoogle Scholar Mohrle et al., 2007 V. Mohrle, M. Stadler, G. Eberz Biosensor-guided screening for macrolide...
Understanding the biosynthetic mechanism of the atypical polyketide extender unit is important for the development of bioactive natural products. Reveromycin (RM) derivatives produced by Streptomyces sp. SN-593 possess several aliphatic extender units. Here, we studied the molecular basis of 2-alkyl...
If fatty acids are added at the beginning of the fermentation process the majority of the fatty acids are involved in the primary metabolism [6]. There are just minor added fatty acids are left when polyketides begin to synthesis. How the residual and minor added fatty acids significantly ...
Integration of multiple copies of biosynthetic genes, overexpression of precursor supply genes, and engineering the redox cofactor all improved the 3HP production, resulting in a strain able to produce 3HP at a titer of 9.8 ± 0.4 g L−1 with a yield of 13 % C-mol C-mol−1 glucose ...
1). Thus, the biosynthetic mechanism for the unusual extender units incorporated into the stambomycins is unclear. Here we report a series of experiments that elucidate the biosynthetic origin and mechanism of assembly of the unusual stambomycin PKS extender units. Incorporation of stable isotope-...
Thus, the biosynthetic mechanism for the unusual extender units incorporated into the stambomycins is unclear. Here we report a series of experiments that elucidate the biosynthetic origin and mechanism of assembly of the unusual stambomycin PKS extender units. Incorporation of stable isotope-labelled...
Characterization of a Pseudomonas aeruginosa fatty acid biosynthetic gene cluster: purification of acyl carrier protein (ACP) and malonyl-Coenzyme A:ACP transacylase (FabD) J. Bacteriol., 181 (1999), pp. 5498-5504 CrossrefView in ScopusGoogle Scholar [7] G.S. Verwoert, E.C. Verbree, K....
Jiang, X.; Meng, X.; Xian, M. Biosynthetic pathways for 3-hydroxypropionic acid production.Appl. Microbiol. Biotechnol.2009,82, 995–1003. [Google Scholar] [CrossRef] [PubMed] De Fouchécour, F.; Sánchez-Castañeda, A.K.; Saulou-Bérion, C.; Spinnler, H.É. Process engineering ...