Malonyl-CoA is a central metabolite across living organisms, serving as the common precursor for fatty acids and their derivatives, including hydrocarbons and fatty acid methyl and ethyl esters, as well as various natural products such as polyketides (for example, the red food colorant carminic ...
Paralleling its role in promoting energy expenditure through FA disposal, PPAR[alpha] also inhibits the lipogenic pathway by induction of the malonyl-CoA decarboxylase which degrades malonyl-CoA, a precursor of FA biosynthesis and inhibitor of the mitochondrial transporter CPT-1 [31] (Figure 1). ...
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Malonyl CoA serves as a substrate in fatty acid biosynthesis while inhibiting fatty acid oxidation. It also acts as a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1 [1] [2]. 化学信息 分子量853.58 分子式C24H38N7O19P3S ...
Natural Product Biosynthesis by Microorganisms and Plants, Part A YoheiKatsuyama,YasuoOhnishi, inMethods in Enzymology, 2012 2.1.3Substrate preparation Malonyl-CoAand many fatty acid CoA esters are commercially available. However, this is not the case for some CoA esters, such as branched-chain or...
Structurally diverse malonyl-CoA building blocks are required to regioselectively diversify macrolide compounds. Specifically, fluorinated building blocks represent pathways to introduce fluorine into drug-like compounds. Herein, the biosynthesis of a tertiary fluorinated malonyl-CoA is described via mutagenesis...
low 3HP yield of malonyl-CoA route.•Genetic selection system was designed to enrich active MCR-C mutants.•MCR-C activity was increased 5.5-fold by directed evolution.•Lowering MCR-N protein level increased 3HP titer significantly.•Best strain produced 40.6g/L 3HPviamalonyl-CoA ...
The cessation of phospholipid biosynthesis by the in-hibition of the -glycerol-3-phosphate acyltransferase using a mutant led to an accumulation of long chain acyl-acyl carrier proteins (acyl-ACP) and the concomitant inhibition of fatty acid biosynthesis in . Malonyl-CoA did not accumulate when ph...
The activity of acetyl-CoA carboxylase (ACC), a rate-limiting enzyme of fatty acid biosynthesis and malonyl-CoA production, can be regulated by several mechanisms, including multisite covalent phosphorylation, both in vitro and in intact... LA Witters,BE Kemp - 《Journal of Biological Chemistry...
These results validated this novel whole-cell biosensor as a rapid and sensitive malonyl-CoA high-throughput screening tool. Further analysis of the mutant strains showed that the iron ion concentration is closely related to the intracellular malonyl-CoA biosynthesis. The online version of this ...