科学家们首先从多个数据库中筛选出与铜死亡相关的LncRNA,通过复杂的机器学习算法,锁定了MAGI2-AS3这一关键分子。接着,他们利用BMSC衍生的EVs作为载体,将MAGI2-AS3送入结直肠癌细胞,观察其对细胞增殖、迁移和侵袭的影响。 在实验过程中,科学家们精心设计了多组对照实验,利用AbMole的CHX等高质量试剂,通过EdU增殖实...
MAGI2-AS3lncRNACancerExpressionBiomarkerMAGI2 Antisense RNA 3 (MAGI2-AS3) is a long non-coding RNA (lncRNA) transcribed from a locus on 7q21.11. This lncRNA has been described to be abnormally expressed in a variety of malignancies in correlation with many clinical characteristics. Moreover...
"Journal of Healthcare Engineering has retracted the article titled “LncRNA MAGI2-AS3 Suppresses the Proliferation and Invasion of Cervical Cancer by Sponging MiR-15b” [1] due to concerns that the peer review process has been compromised. Following an investigation conducted by the Hindawi Resear...
摘要: MAGI2-AS3 impacts ccRCC cell proliferation, migration, and apoptosis.MAGI2-AS3 sponges miR-142-3p, weakening its inhibitory effect on STAM.The MAGI2-AS3/miR-142-3p/STAM axis influences ccRCC cell progression.A prognostic model of genetically related ccRCC was constructed.关键词:...
MAGI2-AS3 was found to be under-expressed in HCC tissues and cell lines. The restoration of MAGI2-AS3 was identified to markedly inhibit HCC cell growth, migrating ability, and invasiveness, and promote cell apoptosis. Interaction between MAGI2-AS3 and KDM1A was identified. KDM1A recruited ...
帕金森病细胞增殖凋亡目的 探讨LncRNA MAGI2-AS3对帕金森病细胞模型损伤的影响及其对miR-1277-5p的调控作用.方法 用1-甲基-4-苯基自由基离子(MPP+)诱导的SK-N-SH细胞建立帕金森病细胞模型,实验分组:MPP++si-NC组,MPP++si-MA-GI2-AS3组,MPP++miR-NC组,MPP++miR-1277-5p组,MPP++si-MAGI2-AS3+anti-miR...
Nevertheless, the function of MAGI2-AS3 remains uncertain in CRC. The expression of MAGI2-AS3, miR-3163, and transmembrane protein 106B (TMEM106B) messenger RNA was examined by quantitative real-time polymerase chain reaction. Cell apoptosis was measured by caspase-3 activity test. Cell ...
MAGI2-AS3 bound with HEY1 and reduced the HEY1 enrichment at the ACY1 promoter region, thus increasing ACY1 gene transcription. HEY1 knockdown or ACY1 overexpression that resisted MAGI2-AS3 knockdown was found in the in vivo and in vitro settings. The present study demonstrates that MAGI2...
检测MAGI2-AS3,miR-218-5p,KDM2AmRNA在CC组织,不同细胞及各组CaSki细胞中的表达水平;检测CaSki细胞增殖,迁移,侵袭,凋亡,Bax,Bcl-2及EMT相关蛋白表达;双荧光素酶实验验证miR-218-5p与MAGI2-AS3,KDM2A的关系.结果CC组织中MAGI2-AS3,KDM2AmRNA表达高于癌旁组织,miR-218-5p低于癌旁组织(P<0.05).HcerEpic...
MAGI2‐AS3 expression in TMZ‐resistant glioblastoma (GBM) cells was analyzed using the Gene Expression Omnibus data set GSE113510?and quantitative real‐time PCR (qRT‐PCR). Cell viability and TMZ half‐maximal inhibitory concentration values were determined using the MTT assay. Apoptosis and cell...