Overexpression of MAGI2-AS3 could reduce ccRCC cell viability and migration, inhibit vessel-like tube formation of HUVECs in vitro, and repress tumor growth and angiogenesis in vivo. MAGI2-AS3 bound with HEY1 and reduced the HEY1 enrichment at the ACY1 promoter region, thus increasing ACY1...
"Journal of Healthcare Engineering has retracted the article titled “LncRNA MAGI2-AS3 Suppresses the Proliferation and Invasion of Cervical Cancer by Sponging MiR-15b” [1] due to concerns that the peer review process has been compromised. Following an investigation conducted by the Hindawi Resear...
LncRNA MAGI2-AS3调控H2O2水平和细胞衰老模式图该研究揭示了细胞氧化还原调控和衰老调控的新因子,表明长链非编码RNA(lncRNA)是氧化还原调节网络和衰老调控的重要成员,为氧化还原生物学研究和衰老干预开拓了新思路。
MAGI2-AS3敲低抑制细胞衰老的潜在分子机制是通过抑制ROS/MAP2K6/p38信号通路介导的。总之,这些研究结果表明,lncRNA MAGI2-AS3的下调通过稳定HSPA8蛋白水平来降低H2O2含量并延迟了细胞衰老,从而表明了其具有潜在的抗衰老应用。 Fig4.长链非编码RNA MAGI2-AS3的下调通过减少HSPA8的降解来减弱H2O2水平并延缓细胞衰老...
Fig4. 长链非编码RNA MAGI2-AS3的下调通过减少HSPA8的降解来减弱H2O2水平并延缓细胞衰老的示意图 原文链接: https://pubmed.ncbi.nlm.nih.gov/35797800/ 一种新型lncRNA RP11-386G11.10重编程脂质代谢以促进肝细胞癌进展 发表期刊:Mol Metab 影响因子:8.568 ...
LncRNA-HOXC-AS3(lnc-HOXC-AS3)是新发现的一种lncRNA,已有研究显示,lnc-HOXC-AS3可调控胃癌、胶质瘤、乳腺癌的肿瘤形成、侵袭和转移[2-3],但lnc-HOXC-AS3在调控胃癌的发生与进展方面的具体机制还需要深入的研究。另一方面,...
综上, LncRNA GAS5, Lnc MAGI2-AS3 具有潜在的增加癌细胞对射线的增 敏作用,其机 制可能与调节基因转录, 增强癌细胞 DNA 损伤和增加抑癌基因 miRNA 的表达有关. 3 LncRNA 在临床对食管癌发生发展的影响 肿瘤的早期筛查,诊断对其治疗和预后具有重 要的推动价 值, 寻找潜在的诊断, 治疗效果评价和 预后...
Li et al. [10] found that lncRNA MAGI2-AS3 promoted tumor progression through sponging miR-141/200a and maintaining overexpression of ZEB1 in gastric cancer. Moreover, lncRNA NR2F1-AS1 promotes GC progression through miR-29a-3p/VAMP7 axis, which may be related to EMT progression in ...
31872979 GRP78 AS lncRNA调控猪骨骼肌纤维脂质沉积的作用机制研究 庞卫军 西北农林科技大学 59万 31872322 新发现的LncRNA TCONS_00323213基因的表达规律及其对猪骨骼肌卫星细胞分化与骨骼肌发育的表观遗传调控 李长春 华中农业大学 59万 31872341 BMP4绑定LncRNA协同组蛋白H3K4甲基化修饰调控鸡PGCs特化的机制 李碧春 ...
[114]. Another peptide MAGI2-AS3-ORF5 interacts with the extracellular matrix to restrict BC cell viability and migration, though its mechanisms require further investigation (Fig.3F) [111]. The discovery of these lncRNA-encoded peptides and their roles in BC, especially TNBC, opens new ...