The role of the long non-coding RNA (lncRNA) MM2P in this function of monocyte-derived cells remained unexplored. Treatment of RAW264.7 murine macrophages and mouse bone marrow-derived macrophages with IL-4 or IL-13 upregulated MM2P expression, upstream of STAT3 and STAT6 phosphorylation. ...
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目的探究胃癌外泌体lncRNA MM2P对巨噬细胞极化的影响及机制.方法诱导THP1细胞分化为M0,M1,M2型巨噬细胞,qRT-PCR检测各组巨噬细胞中lncRNA MM2P表达水平,提取并鉴定胃黏膜上皮细胞GES-1和胃癌细胞株MGC-803,SGC-7901所分泌的外泌体(GES-1 exo,MGC-803 exo,SGC-7901 exo),qRT-PCR检测lncRNA MM2P在胃癌细...
巨噬细胞急性肺损伤lncRNA-MM2P目的:探讨异丙酚(PPF)对急性肺损伤(ALI)小鼠模型肺部浸润巨噬细胞极化的影响及其作用机制.方法:(1)在体实验选取6~8周龄雄性BALB/C小鼠24只,随机分为对照(Control)组,假手术(Sham)组,模型(Model)组和异丙酚治疗(PPF)组,每组6只.构建脂多糖(LPS)诱导的ALI小鼠模型.采用苏木精-...
LncRNA-MM2P Identified as a Modulator of Macrophage M2 Polarizationdoi:10.1158/2326-6066.CIR-18-0145Ji CaoRong DongLi JiangYanling GongMeng YuanJieqiong YouWen MengZhanlei ChenNing ZhangQinjie WengCancer Immunol Res
M2 macrophages,long non-coding RNAs,LncRNA-MM2P,angiogenesis,STAT6Objective:The M2 polarization of macrophages is essential for its function in immunological tolerance,which may promote tumorigenesis.However,the molecular mechanism behind it is not fully understood.In view of most recent clues suggest ...
结果lncRNA MM2P高表达于M2型巨噬细胞(P<0.001),并且lncRNA MM2P在胃癌细胞株及其外泌体中的表达水平均显著高于其在胃黏膜上皮细胞及其外泌体中的表达(P<0.001).与Vector组比较,转染lncRNA MM2P后,M2型巨噬细胞标志蛋白CD206,CD163,IL-10表达显著上调(P<0.001).与GES-1 exo组比较,MGC-803 exo组和SGC...