PSMG3-AS1prostate carcinomamiR-106bmethylationproliferationLong non-coding RNA PSMG3-AS1 is known to play critical roles in several types of cancer, while its role in prostate carcinoma (PC) is unknown. This study aimed to explore the involvement of PSMG3-AS1 in PC. In this study, RT-qPCR...
Figure 1. The pan-cancer analysis demonstrated the expression level of PSMG3-AS1 in variety of cancers. Display full size Figure 2. (a) the TMB analysis based on the expression level of PSMG3-AS1 in variety of cancers; (b) the MSI analysis based on the expression level of PSMG3-AS1 i...
Cell proliferation analysis showed that overexpression of PSMG3-AS1 resulted in increased rate of cell proliferation. Overexpression of miR-449b-5p reduced the enhancing effects of PSMG3-AS1 on cell proliferation. Conclusions: Therefore, miR-449b-5p may target PSMG3-AS1 in LUAD to suppress ...
PSMG3-AS1miR-143-3pCOL1A1proliferationmigrationLong noncoding RNAs (lncRNAs) are considered to be important regulators in breast cancer. In the present study, the potential mechanisms and functional roles of lncRNA PSMG3antisense (AS)1 were investigated invivo and invitro. The relative expression...
LncRNAs PSMG3-AS1 and MEG3 negatively regulate each other to participate in endometrial carcinoma cell proliferationdoi:10.1007/s00335-021-09931-yMammalian Genome - Endometrial carcinoma (EC), also known as corpus cancer or corpus uterine cancer, is the most frequently diagnosed genital cancer among...
Furthermore, we created a disruption vector based on LncRNA PSMG3-AS1 and introduced it into AGS and MKN-45 cells, which are human gastric cancer cells. Significant decreases in the expression of the PSMG3-AS1 gene were noticed in both intervention groups compared to the NC group, reflecting...
Interestingly, PSMG3-AS1 overexpression led to upregulated SphK1, a downstream target of miR-613. In addition, PSMG3-AS1 overexpression reduced the inhibitory effects of miR-613 on NSCLC cell proliferation. Therefore, PSMG3-AS1 may promote the proliferation of NSCLC cells by sponging miR-613 to...