黑加仑提取物肺癌PSMA3-AS1细胞周期凋亡迁移目的:探讨黑加仑提取物对肺癌细胞A549的细胞周期,凋亡和迁移的影响及可能机制.方法:体外培养A549细胞,分为对照组,不同浓度黑加仑提取物组(5 mg/mL,10 mg/mL,15 mg/mL),pcDNA组,pcDNA-PSMA3-AS1组,15 mg/mL黑加仑提取物+pcDNA组,15 mg/mL黑加仑提取物+pcDNA-PSMA3...
他们认为,外泌体lncPSMA3-AS1是通过调节编码蛋白酶体亚基α7的PSMA3的稳定性来介导对蛋白酶体抑制剂耐药的关键决定因素。 PSMA3的上调导致胰凝乳蛋白酶样蛋白酶体活性相关的的α-亚基增加。并且发现,MSCs中的PSMA3和PSMA3-AS1可以包装到外泌体中并转移到骨髓瘤细胞中,进而促进了蛋白酶体抑制剂耐药性的发生。 PS...
基于此,作者们发现在蛋白酶体抑制剂耐药的多发性骨髓瘤患者中,骨髓间充质干细胞(MSCs)来源外泌体可介导PSMA3和lncPSMA3-AS1从间充质干细胞转移至多发性骨髓瘤细胞中,导致其对蛋白酶抑制剂反应差。MSCs中的PSMA3和PSMA3- AS1可以被包装入外泌体并转移到骨髓瘤细胞中,PSMA3- as1可与pre-PSMA3形成RNA双工,通过...
目的 探讨lncRNA PSMA3-AS1调控宫颈癌细胞增殖, 迁移及侵袭的分子机制.方法 收集2020年3月至2021年6月西安医学院第二附属医院收治的42例宫颈癌患者的癌组织及其癌旁组织标本,采用qRT-PCR法检测宫颈癌组织,癌旁组织,人宫颈上皮永生化细胞H8,与人宫颈癌细胞系SiHa,HeLa,Cas-ki中lncRNA PSMA3-AS1,miR-3619-5p的...
PSMA3-AS1miR-411-3pHOXA10GliomaGlioma is a common type of brain tumor and is classified as low and high grades according to morphology and molecules. Growing evidence has proved that long non-coding RNAs (lncRNAs) play pivotal roles in numerous tumors or diseases including glioma. Proteasome ...
Interestingly, miR-329-3p knockdown or ALDOA overexpression partially attenuated the tumor-suppressive effects of PSMA3-AS1 knockdown. Conversely, PSMA3-AS1 overexpression exhibited the opposite effects. PSMA3-AS1 promoted GC progression by regulating the miR-329-3p/ALDOA axis. PSMA3-AS1 might serve...
International Journal of Molecular Sciences Article The Expression Patterns and Implications of MALAT1, MANCR, PSMA3-AS1 and miR-101 in Esophageal Adenocarcinoma Athanasios Syllaios 1,*, Maria Gazouli 2 , Michail Vailas 1 , Konstantinos S. Mylonas 3 , Stratigoula Sakellariou 4, Stavros Sougiou...
PSMA3 antisense RNA1 (PSMA3AS1), a long noncoding RNA, promotes the progression of esophageal squamous cell carcinoma. However, no study to date has explored the expression or roles of PSMA3AS1 in nonsmall cell lung carcinoma (NSCLC). The present study examined the expression profile and ...
PSMA3-AS1 could promote FLT3-ITD+AML progression by regulating the level of autophagy through miR-20a-5p/ATG16L1pathway. In addition, the increase of PSMA3-AS1 may be caused by theinvolvement of METTL3 in regulating its stability. This discovery will providenew horizons fo...
他们认为,外泌体lncPSMA3-AS1是通过调节编码蛋白酶体亚基α7的PSMA3的稳定性来介导对蛋白酶体抑制剂耐药的关键决定因素。 PSMA3的上调导致胰凝乳蛋白酶样蛋白酶体活性相关的的α-亚基增加。并且发现,MSCs中的PSMA3和PSMA3-AS1可以包装到外泌体中并转移到骨髓瘤细胞中,进而促进了蛋白酶体抑制剂耐药性的发生。 PS...