A novel 8-gene signature was constructed to predict prognosis based on 465 macrophage marker genes identified by an analysis of single-cell RNA sequencing data of LUAD, and was also verified in 4 independent GEO cohorts. The MMGS significantly classified patients into high-risk and low-risk ...
While CD68 is not a specific marker for M1 macrophages, its expression has been upregulated in M1 macrophages compared to M2 macrophages. CD11b: CD11b, also known as integrin alpha M (ITGAM), is a surface receptor that is primarily expressed on the surface of myeloid cells, including ...
It is now appreciated that the M2 group encompasses a functionally diverse group of macrophages that can be further subdivided into four subsets; M2a, M2b, M2c, and M2d based on their distinct gene expression profiles. As shown in table 5 below, the M2a subtype is elicited by IL-4, IL-...
Both PKM2I428&429A and PKM2R399E functioned in ectosome-induced gene expression of differentiation-associated transcription factors and macrophage differentiation as effectively as PKM2WT, but PKM2I267&268A failed to exert the same effects (Figures 5E–5H). Thus, the regulation of monocyte-to-...
The following table provides a broad list of proteins expressed by macrophages, as mentioned by various sources. They are categorized by their human NCBI gene symbol (Gene), common names (Synonyms), expression in human or mouse (Species), type of macrophage marker (Marker Type), protein type,...
Based on the gene expression level of each sample in the GSE32707 dataset, the enrichment level of 28 immune cells in each sample in the dataset was analysed using the ssGSEA method in R language. The corrplot package was used to analyse the relationship between the individual immune cell lev...
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We then genetically ablated the Mdh1 gene by transducing BMDMs from LysM-Cre Cas9 mice with lentiviruses expressing an sgRNA targeting Mdh1 (Extended Data Fig. 6g). We found that FGK45 treatment failed to induce the expression of pro-inflammatory marker genes and the production of cytokines in ...
(D) iNOS gene expression assessed by qPCR. Data are mean ± SEM. **P < 0.01 versus Normal group, #P < 0.05 and ##P < 0.01 versus Model group. 3.6. Geniposide elevates the protein and mRNA amounts of the macrophage M2 phenotypic marker Arg-1 in aortic tissues Macrophage polarization ...
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