Macrophage-expressed gene (Mpeg)1.1 is an evolutionary conserved gene encoding perforin-2, a pore-forming protein associated with host defense against pathogens. Zebrafish mpeg1.1:GFP and mpeg1.1:mCherry reporters were originally established to specifically label macrophages. Since then more than 100 ...
Macrophage-expressed gene 1 (MPEG1/Perforin-2) is a perforin-like protein that functions within the phagolysosome to damage engulfed microbes. MPEG1 is thought to form pores in target membranes, however, its mode of action remains unknown. We use cryo-Electron Microscopy (cryo-EM) to determine...
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中文名称: Recombinant Macrophage Expressed Gene 1 Protein (MPG1) 中文同义词: 巨噬细胞表达基因1蛋白(MPG1)重组蛋白 英文名称: Recombinant Macrophage Expressed Gene 1 Protein (MPG1) 英文同义词: Recombinant Macrophage Expressed Gene 1 Protein (MPG1) CAS号: 分子式: 分子量: 0 EINECS号: Mol文件...
the Iba1 gene is highly conserved throughout evolution, suggesting an important role for this protein. Recent molecular studies pointed out a possible role in membrane ruffling and phagocytosis. The ubiquitous intracellular localization of Iba1 provides good staining, delineating whole microglial cells wh...
Figure 1 GSE32707 differential gene expression screening and enrichment analysis. (A) Volcano plot of differentially expressed genes between the sepsis group and control group in the GSE32707 dataset. (B) Volcano plot of differentially expressed genes between the sepsis-induced ARDS group and control...
and MAPK pathways are also involved in M1 and M2 polarization. The JAK/STAT pathway is activated by cytokines such as IFN-γ and IL-4 and promotes the activation of STAT1 and STAT6, respectively. The PI3K/Akt pathway is activated in M2 macrophages and promotes M2-associated gene expression ...
000 differentially expressed gene lists from cell lines exposed to around 6,000 small molecules. Using fGSEA, 906 signatures mimicked the effect of disruptingETS2(Padj < 0.05), including several approved IBD therapies. The largest class of drugs was MEK inhibitors (Fig.5g), which are ...
This gene is heavily transcribed in the macrophages derived from the susceptible mice (Additional file 1: Table S1). Thus, if expressed, this protein may protect the cells from the apoptosis induced by the ROS which may allow the parasite to survive and thus may contribute to the susceptible ...
描述: Recombinant Mouse Matrix Metalloproteinase 12 is produced by our Mammalian expression system and the target gene encoding Ala29-Cys473 is expressed with a 6His tag at the C-terminus. Accession: P34960 中文别名: Macrophage Metalloelastase蛋白; MMP12蛋白 来源: Human Cells 纯度: Greater than...