Trehalose-6,6′-dibehenate (TDB) displays moderate anti-tumour activity and stimulates M1-like macrophages via the macrophage inducible C-type lectin (Mincle) resulting in IL-1β production. In this study, we examined if monosodium urate (MSU), a known vaccine adjuvant, can boost IL-1β ...
Here we show that toll-like receptor 2 (TLR2) and NLRP3 inflammasome activation in cardiac macrophages mediate the production of IL-1β in DM mice. IL-1β causes prolongation of the action potential duration, induces a decrease in potassium current and an increase in calcium sparks in ...
M2b macrophages: Activation by immune complexes, Toll-like receptor (TLR) ligands and IL-1b. Upon activation, this subtype releases pro- and anti-inflammatory cytokines TNF-α, IL-1b, IL-6, and IL-10. M2b macrophages function in the regulation of the immune r...
M2b macrophages: Activation by immune complexes, Toll-like receptor (TLR) ligands and IL-1b. Upon activation, this subtype releases pro- and anti-inflammatory cytokines TNF-α, IL-1b, IL-6, and IL-10. M2b macrophages function in the regulation of the immune r...
M1 macrophage polarization is driven by the transcription factors interferon regulatory factor 5 (IRF5) and nuclear factor-kappa B (NF-κB). Upon activation by IFN-γ or LPS, IRF5 and NF-κB translocate to the nucleus and promote the expression of pro-inflammatory cytokines, such as IL-1β...
Macrophage exposure to HCV induces inflammasome signaling of IL-1β and proinflammatory cytokine and chemokine expression.Amina A. NegashHilario J. RamosNanette CrochetDaryl T. Y. LauBrian DoehleNeven PapicDon A. DelkerJuandy JoAntonio Bertoletti...
重组大鼠巨噬细胞炎症蛋白-1 B(CCL4)是在大肠杆菌中重组表达的,是一条非糖基化的多肽链,包含有 69 个氨基酸 分子量为 7.8 kDa. The MIP-1b 最终由标准的色谱技术纯化获得..
Consistent with the changes in total IL-1RI protein expression, the cell surface expression of IL-1RI increased most noticeably at 6 h after LPS treatment and lasted for 24 h after the treatment (Fig. 1B). To further verify the effect of LPS on IL-1RI expression, AM were isolated...
Corrigendum to “Leptospira interrogans infection leads to IL-1β and IL-18 secretion from a human macrophage cell line through reactive oxygen species and cathepsin B mediated-NLRP3 inflammasome activation” [Microbe Infect (2018) 254–260] Microbes and Infection, Volume 23, Issue 1, January–Feb...
M1 M2a M2b M2c M2d Activation IFN-g, LPS, CM-CSF IL-4, IL-13, Fungal infection, Helminth infection Immune Complexes, IL-1R IL-10, TGF-b IL-6, LIF, Adenosine Cytokine secretion TNF, IL-1b, IL-6, IL-12 Il-23 IL-10, TGF-b, IL-1ra IL-1, IL-6, IL-10, TNF-a IL-10...