Lymphocyte function-associated antigen-1 (LFA-1; [ 1 ]) and macrophage antigen-1 (Mac-1; [ 2 ]) are some of the best-characterized integrins. Like other integrins, their diverse relationships and functions have lead to complex nomenclature. Integrins are heterodimeric receptors, consisting of ...
Mac-1 (macrophage-1 antigen) is a heterodimer consisting of αM (CD11b) and β2 (CD18) chains. Integrin αM (CD11b) is expressed in myeloid-lineage cells such as monocytes/macrophages, neutrophils, eosinophils, and basophils, and in lymphoid cells such as NK cells and peritoneal B-1 ce...
Mac-1 and LFA-1 comprise a novel family of two-chain leukocyte differentiation antigens.doi:10.1038/296668a0Kürzinger, KonradHo, May-KinSpringer, Timothy A.NatureStructural homology of a macrophage differentiation antigen and an antigen involved in T-cell-mediated killing. Nature (Lond - Kir...
These results suggest that insulin stimulates monocyte trans-endothelial migration through Akt-dependent surface expression of Mac-1, which may be part of the atherogenesis in type 2 diabetes.doi:10.1016/j.bbadis.2014.06.003Jin, S. Y.Kim, E. K....
Mice injected intraperitoneally with either M-CSF plus LPS, LPS alone, M-CSF alone or saline every day for 8 days were examined for the degree of urine albumin excretion and lymphocyte-function associated antigen-1-positive (LFA-1 + ) cells in peripheral blood as well as renal pathology. ...
Macrophages, being the cornerstone of the immune system, have adapted the ancient nutrient acquisition mechanism of phagocytosis to engulf various infectious organisms thereby helping to orchestrate an appropriate host response. Phagocytosis refers to the process of internalization and degradation of particulat...
The dysregulation of intestinal macrophage homeostasis and the loss of antigen tolerance can result in the development of numerous inflammatory diseases, with IBD being a common example [57]. IBD is a category of recurrent inflammatory diseases that currently has no effective treatment owing to the ...
N. Liver antigen-presenting cells. J. Hepatol. 54, 357–365 (2011). Article CAS PubMed Google Scholar Sierro, F. et al. A liver capsular network of monocyte-derived macrophages restricts hepatic dissemination of intraperitoneal bacteria by neutrophil recruitment. Immunity 47, 374–388.e6 (...
Other functions, other genes: alternative activation of antigen- presenting cells Immunity, 10 (1999), pp. 137-142 View PDFView articleView in ScopusGoogle Scholar Gordon, 2003 S. Gordon Alternative activation of macrophages Nat. Rev. Immunol., 3 (2003), pp. 23-35 CrossrefView in ScopusGoog...
either as stationary or as mobile cells. They also stimulate lymphocytes and other immune cells to respond to pathogens. Macrophages can be identified by specific expression of a number of proteins including CD14, CD11b, F4/80 (mice)/EMR1 (human),Lysozyme M, MAC-1/MAC-...