Mac-1 (macrophage-1 antigen) is a heterodimer consisting of αM (CD11b) and β2 (CD18) chains. Integrin αM (CD11b) is expressed in myeloid-lineage cells such as monocytes/macrophages, neutrophils, eosinophils, and basophils, and in lymphoid cells such as NK cells and peritoneal B-1 ce...
Macrophage‐1 antigen (Mac‐1, CD11b/CD18), which is expressed on the surface of leukocytes, is known to promote NET formation. This study aimed to elucidate the role of Mac‐1 in extracellular histone‐induced ALI. Exogenous histones were administered to Mac‐1‐deficient...
The meaning of MACROPHAGE is a phagocytic tissue cell of the immune system that may be fixed or freely motile, is derived from a monocyte, functions in the destruction of foreign antigens (such as bacteria and viruses), and serves as an antigen-presentin
Any of various large, phagocytic white blood cells that develop from monocytes, are found in the spleen, liver, and other tissues, and have a variety of functions in the immune system including engulfing and destroying pathogens and dead cells, presenting antigens to activate lymphocytes, and rel...
Monoclonal antibodies have been obtained that react with the murine leukocyte surface glycoproteins bearing the macrophage differentiation antigen Mac-1. Structural and antigenic analysis shows that related glycoproteins are found on other murine hematopoietic cell types. The data not only illustrate the com...
1.2 Background and product applications CD11b MicroBeads are developed for separation of human and mouse cells based on expression of the CD11b antigen. In humans, CD11b is strongly expressed on myeloid cells, and weakly expressed on NK cells and some activated lymphocytes. In mouse, the CD...
Table 3.Cell surface antigens that are commonly used for the flow cytometric analyses of mouse immune cells. Antigen nameOther nameCells CD3T,NKT CD4T,DC, Mono CD8T,DC CD11bMac-1, ItgamMac,Mono, Neu, NK, T, B CD11cItgaxDC, Mono, Mac, NK, T, B, Grn ...
CD18 (Cell Surface Adhesion Glycoproteins LFA 1/CR3/p150,95 Subunit beta, Complement Receptor C3 Subunit beta, Integrin beta 2, ITGB2, LAD, LCAMB, Leukocyte Cell Adhesion Molecule CD18, LFA1, LFA-1, Lymphocyte Function Associated Antigen 1, MAC-1, Macrophage Antigen 1 (mac1) beta Subunit...
This upregulation leads to the effective activation of MR receptor‒ligand binding, resulting in increased macrophage phagocytosis and antigen presentation. These findings suggest promising therapeutic avenues for the treatment of inflammatory diseases. The Dectin-1 receptor, alternatively referred to as ...
We develop precision medicines to modulate macrophages for the treatment of cancer, by bringing together world-leading cancer biologists.