Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature. 2007;447:1116-1120.Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, Morel CR, Subramanian V, Mukundan L, Red Eagle A, Vats D, Brombacher F, Ferrante AW, Chawla A: Macrophage-specific PPARgamma ...
Macrophage-specific overexpression of CEH led to a significant reduction in the lesion area and cholesterol content of high-fat, high-cholesterol diet–induced atherosclerotic lesions. The lesions from Ldlr–/–CEHTg mice did not have increased FC, were less necrotic, and contained significantly highe...
To address this problem, we adopted a(TRAP)- approach and designed a transgene that expresses an eGFP-tagged ribosomal protein (L10a) under the control of the macrophage-specific c-fms promoter to generate c-fms-eGFP-L10a transgenic mice (Mac). Rigorous characterization found no gross ...
Macrophage-specific PPARgamma controls alternative activation and improves insulin resistanceAnimalsMice, Inbred BALB CMice, KnockoutMice... JI Odegaard,RR Ricardo-Gonzalez,MH Goforth,... - 《Nature》 被引量: 3513发表: 2007年 Odegaard, J.I. et al. Macrophage-specific PPAR controls alternative ac...
www.nature.com/scientificreports OPEN Development of a new macrophage-specific TRAP mouse (MacTRAP) and definition of the renal macrophage translational signature Andreas Hofmeister1, Maximilian C. Thomaßen1, Sabrina Markert1, André Marquardt2, Mathieu Preußner1, Martin Ruß...
Small cell carcinoma of the lung: macrophage-specific antigens suggest hemopoietic stem cell origin Four surface antigens previously recognized only in macrophages are present on human small cell lung carcinoma cells and tumors. Cancerous cells may arise from macrophage precursors in bone marrow, and...
Macrophage specific antigens were detected with fluorescein and 125I-labeled rabbit antibodies to anti-guinea pig macrophages on surface membranes of 85–100% of peritoneal exudate macrophages (PEM), 35–90% of alveolar macrophages (AVM), 35–50% of splenic macrophages, and 10% of peripheral blo...
To express GCase from theCCR5locus, we used a previously characterized derivative of the CD68 promoter and confirmed through in vitro and in vivo differentiation protocols that it achieves monocyte/macrophage-specific expression of GCase30,31. We reasoned that because the primary manifestations of Gau...
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Macrophage-specific expression of urokinase-type plasminogen activator promotes skeletal muscle regeneration. Macrophages (Mp) and the plasminogen system play important roles in tissue repair following injury. We hypothesized that Mp-specific expression of urokinas... ML Novak,SC Bryer,M Cheng,... - ...