巨噬细胞通常存在于两个不同的亚群: 1)经典激活或M1巨噬细胞,它们是促炎细胞,并被脂多糖(LPS)单独或与Th1细胞因子(如IFN-γ,GM-CSF)联合极化,并产生促炎细胞因子,如白细胞介素-1β (IL-1β), IL-6, IL-12, IL-23和TNF-α; 2)交替激活或M2型巨噬细胞,具有抗炎和免疫调节作用,被Th2细胞因子IL-4...
样本:Macrophage mannose receptor 1 ELISA Kit 检测方法:详见说明书 应用:ELISA 检测限:0.156-10 ng/mL 货号:BK-F101153 是否进口:是 Macrophage mannose receptor 1 ELISA Kit的详细说明书 检测范围:0.156-10 ng/mL 使用:本试剂仅供科研使用 保存:2-8℃ ...
Celastrol down-regulated the mRNA levels of macrophage M1 biomarkers (e.g., IL-6, IL-1β, TNF-α, iNOS) in cell culture and in mice. The underlying mechanisms were investigated in murine macrophage RAW264.7 cells. Our results demonstrated that celastrol might control macrophage polarization ...
macrophages to D-mannose, which impairs glucose metabolism by raising intracellular mannose-6-phosphate levels. Such alterations result in the suppression of succinate-mediated HIF-1α activation, imposing a consequent reduction of LPS-inducedIl1bexpression. Disclosing an unrecognized metabolic hijack of ...
112P Macrophage inhibitory cytokine-1 as a biomarker for diagnosis and prognosis of stage I-II non-small cell lung cancer Background and objective Increased macrophage inhibitory cytokine-1 (MIC-1), member of transforming growth factor-β (TGF-β) superfamily, was found in patients serum with ...
Kaler, P., Augenlicht, L. & Klampfer, L. Macrophage-derived IL-1β stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3.Oncogene28, 3892–3902 (2009). https://doi.org/10.1038/onc.2009.247 ...
Obesity-associated chronic inflammation is characterized by an accumulation of adipose tissue macrophages (ATMs). It is generally believed that those macrophages are derived from peripheral blood monocytes. However, recent studies suggest that local proliferation of macrophages is responsible for ATM accumula...
1. Description Components 2 mL CD11b MicroBeads, mouse/human:MicroBeads conjugated to monoclonal rat anti-mouse/human CD11b (Mac-1α) antibodies (isotype: rat IgG2b; clone: M1/70.15.11.5). Size For 1×109 human total cells, up to 100 separations; for 2×109 mouse total cells, up ...
Background Intensive insulin treatment is associated with an increased risk of hypoglycemia, so strict glycemic monitoring is essential. The best type of sample for identifying hypoglycemia remains under debate. Objectives To establish the number of hypoglycemic events in intensive care patients relative ...
Fig. 1 Origin of intestinal macrophages. (Created with BioRender.com) Full size image Macrophages, which are critical effector cells in the innate immune system, are abundant in tissues and essential for the regulation of intestinal homeostasis and inflammation, particularly in the gut [17]. Intest...