Notably, the effects on targeted mRNAs resulted by m6A predominantly depend on the functions of different m6A-binding proteins ("readers") including YT521-B homology (YTH) domain family, heterogeneous nuclear ribonucleoproteins (HNRNPs), and insulin-like growth factor 2 mRNA-binding proteins (IGF2...
Diverse RNAs and RNA-binding proteins form phase-separated, membraneless granules in cells under stress conditions. However, the role of the prevalent mRNA methylation, m6A, and its binding proteins in stress granule (SG) assembly remain unclear. Here, we show that m6A-modified mRNAs are enriched...
IGF2BP s(insulin-like growth factor 2 mRNA-binding proteins)蛋白具有多个串联的KH结构域,也是一类RBP。最近,IGF2BPs被作为一个潜在的m6A“读码器”蛋白被报道。它可以增强mRNA的稳定性,并且可以通过m6A依赖的方式介导RNA的翻译过程[66]。其他被报道可能作为m6A“读码器”的蛋白还包括eIF3(eukaryotic initiation ...
鉴于这些SG蛋白与m6A-RNA和m6A结合蛋白的特定结合行为,由此产生了一个重要的科学问题,即m6A-RNA、以及m6A结合蛋白是否在SG形成过程中发挥某些特殊的作用? 在于202年5月25日以m6A-binding YTHDF proteins promote stress granule formation为题...
在于202年5月25日以m6A-binding YTHDF proteins promote stress granule formation为题在线发表在Nature Chemical Biology的文章中,来自哈佛大学霍华德·休斯医学院的庄小威(Xiaowei Zhuang)教授实验室(一作为博士后研究员Ye Fu)研究了m6A-mRNA和m6A结合蛋白YTHDF在哺乳动物细胞中的定位,并确定了m6A结合蛋白YTHDF是SG形成中...
(TNF-R2), by extending the half-life of m6A-modified TNFRSF1B transcripts in leukemia cells [38,63]. Previous studies indicated that TNFR2 binds to its ligand TNF, to mediate the binding of some adaptor proteins, which in turn initiate signal transduction to regulate cell death [80]. ...
IGF2BP s(insulin-like growth factor 2 mRNA-binding proteins)蛋白具有多个串联的KH结构域,也是一类RBP。最近,IGF2BPs被作为一个潜在的m6A“读码器”蛋白被报道。它可以增强mRNA的稳定性,并且可以通过m6A依赖的方式介导RNA的翻译过程[66]。其他被报道可能作为m6A“读码器”的蛋白还包括eIF3(eukaryotic initiation...
25. Huang, H. et al. Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat. Cell Biol. 20, 285–295 (2018). 26. Meyer, K. D. et al. 5’ UTR m(6)A prom...
2019年7月11日，来自CornellUniversity的SamieR.Jaffrey课题组在Nature上发表了题为m6AenhancesthephaseseparationpotentialofmRNA的文章，报道了m6A修饰可以促进mRNA与YTHDF蛋白发生相分离从而影响了一系列的细胞生物学过程。 另外，几乎同时，庄小威实验室也在bioRxiv上online了题为m6A-bindingYTHDFproteinspromotestressgranule...
4. Chen, X., Zhou, X. & Wang, X. m6A binding protein YTHDF2 in cancer. Exp Hematol Oncol 11, 21 (2022). 5. Liao, J. et al. Insight into the structure, physiological function, and role in cancer of m6A readers—YTH domain-containing proteins. Cell Death Discov. 8, 137 (2022)...