surface of monocytes and macrophages. M2 macrophages express high levels of CD163 and other M2-associated markers such as CD206 and arginase-1. CD163 has been shown to play a role in the regulation of inflammation, as well as in the clearance of hemoglobin and the prevention of oxidative ...
参考文献:Jablonski KA, Amici SA, Webb LM, Ruiz-Rosado Jde D, Popovich PG, Partida-Sanchez S, Guerau-de-Arellano M. Novel Markers to Delineate Murine M1 and M2 Macrophages. PLoS One. 2015 Dec 23;10(12):e0145342. doi: 10.1371/jou...
Liver fibrosis is a severe stage of nonalcoholic fatty liver disease (NAFLD), which is closely associated with the activation of hepatic stellate cells (HSCs) and their interaction with macrophages. Exosomes can mediate c...
CONCLUSIONS: GBM cells express macrophage activation markers CD163, CD204 and CD206, which is a novel observation. This finding implies the existence of a subset of GBM cells with a potential important functional role in the tumor microenvironment. Also, more specific markers for M2 macrophages ...
2022的一篇CELL文章:《Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer》就提到了里面的巨噬细胞可以分类成为2个: (1) TREM2+ macrophages expressing triggering receptor expressed by myeloid cells-2 (TREM2) and osteopontin (SPP1) genes, ...
Because iNOS expression is a marker of M1 macrophages23 and Th2 immunity induce M2 macrophages, we decided to investigate the expression of M1 and M2 markers in the lung. For this purpose, we evaluated iNOS expression as a M1 marker and Arg1, Fizz1 and Ym1 gene expression as M2 markers....
Rőszer T. Understanding the mysterious M2 macrophage through activation markers and effector mechanisms[J]. Mediators of inflammation, 2015, 2015. Park M D, Silvin A, Ginhoux F, et al. Macrophages in health and disease[J]. Cell, 2022, 185(23): 4259-4279. ...
and tissue repair. Macrophages are also crucial in the pathogenesis of immune-inflammatory disorders, such as, arthritis. In this review, we discuss the markers of human M2 macrophages, the role played by them in inflammation or progression of rheumatic diseases, their potential to act as biomarke...
然后提取里面的巨噬细胞,进行细致的分析,比如绘制 Scatter plot of CXCL9 and SPP1 expression in each of 16,292 macrophages 16,292 macrophages 仔细看看这里的CXCL9 and SPP1的排他性,跟前面提到的TREM2联合SPP1,去和FOLR2基因的排他性,是不是一回事?
3A, diffuse red fluorescence could be found around the nuclei of macrophages, suggesting the successful uptake of MEs by RAW 264.7 cells. Second, flow cytometry was performed to quantitatively analyse macrophage polarization after different stimulations. CD206 and CD86 were used as markers of...