The decrease in both M1 and M2 macrophage markers by calcitriol or their negative correlation with CYP27B1 indicate the modulatory, but rather anticancer activity of VD. The intensity of these effects was the s
tissue repair. M2 macrophages also express high levels of surface markers such as CD163 and CD206, which are associated with tissue repair and immunosuppression. In contrast to M1 macrophages, M2 macrophages rely on oxidative phosphorylation for their energy metabolism and produce lower levels of ...
Plos One上面有篇2015年的文章《Novel Markers to Delineate Murine M1 and M2 Macrophages - PubMed[5]》,比对了野生型C57BL/6J小鼠M0、M1、M2巨噬细胞转录产物的差异(上调、下调),再经过验证,发现在流式上,CD38/Egr2可很好的区...
提出来的是CXCL9andSPP1(CS) expression but not by conventional M1 and M2 markers,而且是公布了数据:https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?
Plos One上面有篇2015年的文章《Novel Markers to Delineate Murine M1 and M2 Macrophages - PubMed [5]》,比对了野生型C57BL/6J小鼠M0、M1、M2巨噬细胞转录产物的差异(上调、下调),再经过验证,发现在流式上,CD38/Egr2可很好的区分M1和M2,见下图,当然CD38/iNOS也是非常好的区分标记。虽然是7年前,但是也被...
to control macrophage cell shape directly, we demonstrate here that elongation itself, without exogenous cytokines, leads to the expression of M2 phenotype markers and reduces the secretion of inflammatory cytokines. Moreover, elongation enhances the effects of M2-inducing cytokinesIL-4andIL-13and prot...
Diverse bioenergetic profiles of M1/M2 macrophages exposed to anthocyanins and their phenolic metabolitesDifferentiation of monocytes occurs at the site of inflammation into the pro-inflammatory (M1, glycolytic) or anti-inflammatory (M2, oxidative) phenotype. Chronic disorders associated with low-grade ...
巨噬细胞Macrophages一个重要的特性就是具有很高的可塑性(通俗的讲就是多变,随所处环境的变化而变),面对不同的病原体或刺激因素时可以向不同方向分化。根据极化后巨噬细胞的表面标志物及其功能,将其分为M1型(经典活化)巨噬细胞和M2型(替代激活)巨噬细胞两种主要表型。切记,巨噬细胞macrophages的极化M1和M2是...
还有一个新鲜出炉(2023年8月)的science杂志文章:《CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers》,提出来的是CXCL9andSPP1(CS) expression but not by conventional M1 and M2 markers,而且是公布了数据:https://www.ncbi.nlm.nih.gov/geo/query/acc....
还有一个新鲜出炉(2023年8月)的science杂志文章:《CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers》,提出来的是CXCL9andSPP1(CS) expression but not by conventional M1 and M2 markers,而且是公布了数据:https://www.ncbi.nlm.nih.gov/geo/query/acc....