metabolic pathways that are critical for macrophage polarization. In a proof-of-principle approach, we use these datasets to show that MEK signaling is required for M2-type polarization by promoting peroxisome proliferator-activatedreceptor-γ(PPARγ)-induced retinoic acid signaling. 经历M1 型极化和 M...
Taken together, these results indicated that DHA enhanced the expression of M2 macrophage markers through the p38 MAPK signaling pathway and autophagy, suggesting that DHA regulates M2 macrophage polarization and plays an important role in innate immunity.doi:10.1002/jcb.28527...
在信号通路分析方面,丰富在 “Cytoskeletal regulation by RhoGTPase”、“Signaling by Rho GTPases”、“TGF-beta signaling pathway”、“EGF receptor signaling pathway”,其次是信号转导、趋化因子信号通路、免疫系统等。进行GSEA分析,发现 CCR3 抑制剂组与细胞分裂、细胞粘附、扩张型心肌病和肥厚型心肌病呈负相关...
4月12日,基础医学院程金科教授实验室在Cell Reports发表了题为“SENP1-Sirt3 signaling promotes α-ketoglutarate production during M2 macrophage polarization” 的研究论文,报道了SENP1-Sirt3信号轴通过调控谷氨酰胺代谢促进α酮戊二酸产生和巨噬细胞M2型极化的新机制 4月12日,基础医学院程金科教授实验室在Cell ...
该文章“Effective-components combination improves airway remodeling in COPD rats by suppressing M2 macrophage polarization via the inhibition of mTORC2 activity”于2021年9月发表于Phytomedicine杂志上。 研究背景 慢性阻塞性肺疾病(COPD...
联合深圳中山妇产医院李龙飞博士团队,在《Journal of Translational Medicine》(WOS 1区,中科院医学2区,IF7.4)在线发表题为“Trophoblast-derived miR-410-5p induces M2 macrophage polarization and mediates immunotolerance at the fetal-...
浙江大学医学院附属第一医院马量老师团队在《Cell Biol Toxicol》发表了题目为:CCL24/CCR3 axis plays a central role in angiotensin II-induced heart failure by stimulating M2 macrophage polarization and fibroblast activation的研究论文,本研究旨在探讨多效性趋化因子CCL24在心力衰竭中的作用机制。
of STAT6 and enhances the expression of PPARδ. We further found that macrophage M2 polarization is reduced when the STAT6/PPARδ pathway is inhibited. Together, these data show a role for the STAT6/PPARδ signaling pathway in the CD137 signaling-induced M2 macrophage polarization pathway. ...
These results indicate that HCVc suppressed both M1 and M2 macrophage polarization, which is consistent with chronic HCV infection. HCVc inhibits macrophages polarization through TLR2/STATs signaling pathway. We further investigated whether the inhibition of macrophages polarization by HCVc is ...
Key words: stem cells, dental pulp stem cells, hypoxia, exosomes, macrophages, polarization, STAT3, NF-κB, signaling pathway 中图分类号: R459.9 R318 R781.31 引用本文 谭旭, 梁羽, 梁燕, 廖健. 缺氧处理牙髓干细胞外泌体诱导M2巨噬细胞极化[J]. 中国组织工程研究, 2022, 26(25): 3961...