Macrophage polarizationNotch signaling pathwayLiver diseasesThe liver is not only the main metabolic site of exogenous compounds and drugs, but also an important immune organ in the human body. When a large number of nonself substances (such as drugs, alcohol, pathogens, microorganisms and their ...
Baricitinib attenuates pulmonary fibrosis in scleroderma mice by regulating macrophage polarization 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway to reduce the severity of pulmonary fibros...
ω-3 PUFAs are known ligands of PPARγ, a transcription factor that promotes M2 macrophage polarization by regulating the expression of FAO-associated genes. On the other hand, ω-3 PUFAs can impede NF-κB-dependent transcription of genes associated with inflammation and autoimmunity, thereby supp...
Macrophages play an important role in the development of age-related macular degeneration (AMD). In this study, the spatial and temporal changes and the polarization of macrophages in murine laser-induced choroidal neovascularization (CNV) were investigated and the polarized M1 and M2 biomarkers in t...
Pathways of macrophage polarization in IBD NF-κB signaling pathway NF-κB comprises p50, p65, and inhibitory IkappaB (IκB) in a homodimeric or heterodimeric complex. Under normal conditions, these protein complexes are inactive in the cytoplasm. When the trigger factor activates the receptor, I...
(Camille and Dealtry, 2018) which is important for the resolution of inflammation and wound healing. Probably first time we reported how fruit components (vitexin + verapamil) regulated macrophages polarization through inhibition of P-gp expression via TLR4-NF-κB-TNFR2 pathway in peritoneal ...
Treatment of particle-challenged monocyte/macrophages with IL-4 led to an initial suppression of pro-inflammatory cytokines and inducible nitric oxide synthase (iNOS) production and subsequent polarization into an M2 anti-inflammatory phenotype. This result was optimized when IL-4 was delivered before ...
MSC-EVs promoted the polarization of macrophages from M1 to M2 phenotypes both in vivo and in vitro. On the other hand, M2 macrophage polarization was partially eliminated by diminishing the expression of MSC-EV miR-182, which targeted TLR4-mediated signaling pathways in macrophages [80]. In a...
and various pro-inflammatory factors in lymph nodes, among which TGF-β secreted by Treg cells is of particular significance in the inhibition of M1 polarization by acupuncture [28]. However, whether acupuncture regulates T cells as an upstream pathway of macrophage polarization needs further confirma...
Protumoral TSP50 regulates macrophage activities and polarization via induction of TNF-α production and NF-κB signaling pathway Yang C, Zhang DM, Song ZB, Hou YQ, Bao YL, Sun LG, Yu CL and Li YX. Protumoral TSP50 Regulates Macrophage Activities and Polarization via Production of TNF-alpha...