At sufficient concentrations, these granule preparations can effect complete lysis of P815 or EL4 tumor cell populations within minutes.doi:10.1016/0167-5699(84)90130-0Eric MartzElsevier B.V.Immunology TodayLytic granules, adhesion molecules, and other recent insights - Martz - 1984...
Page LJ, Darmon AJ, Uellner R und Griffiths GM (1998): L is for lytic granules: lysosomes that kill. Biochim Biophys Acta 1401, 146-156Page LJ, Darmon AJ, Uellner R, Griffiths GM: L is for lytic granules: lysosomes that kill.
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usually the endoplasmic reticulum, and the subsequent monitoring of their traffic toward acceptor compartments. Here we describe the RUSH system applied to cytotoxic T cells to characterize the biogenesis of lytic granules, using as a
2e). Interestingly, γδD4 T cells also had more chondroitin sulfate, which is associated with serglycin, a core protein within the dense core of cytotoxic granules, (Fig. 2d, e and Supplementary Fig. 2f) but the same level of CD63, a late endosomal/lysosomal marker, (Supplementary Fig...
Summary: Cytotoxic T lymphocytes (CTLs) kill targets by releasing cytotoxic agents from lytic granules. Killing is a multi-step process. The CTL adheres to a target, allowing its T-cell receptors to recognize antigen. This triggers a signal transduction cascade that leads to the polarization...
Here, we investigate the role of Syntaxin7 (Stx7) in the release of lytic granules from cytotoxic T lymphocytes (CTLs). We show that Stx7 is expressed in CTLs and is preferentially localized to the region of lytic granule release, the immunological synapse (IS). Interference of Stx7 ...
adaptor protein 1 (AP-1) sorting complex, also causes retention of perforin in the transport vesicles and inhibits cytotoxicity, indicating that the interaction between AP-1 sorting complex and LAMP1 on the surface of the transport vesicles is important for perforin trafficking to lytic granules. ...
The protective efficacy of CoCl2 (and probably that of NiCl2) was most likely due to its capacity to reduce or block the generation by lytic granules/perforin of large-conductance (approximately 1400 pS) channels responsible for inducing Ca++ overload and cell destruction. We consider these ...
cells that kill fewer target cells often use death receptor signalling or a so far unidentified mechanism. Super-resolution fluorescence and electron microscopy imaging show that the spatial distribution of granzyme B and perforin in the lytic granules is imbalanced, consistent with perforin being limiti...