The function of lytic granules in tumor therapy induced by IL-2 activated killer lymphocytesThe function of lytic granules in tumor therapy induced by IL-2 activated killer lymphocytes - European Journal of Cancerdoi:10.1016/0959-8049(93)90669-7Berke...
In NK cells from patients with a truncation mutation in myosin IIA, NK cell cytotoxicity, lytic granule penetration into F-actin at the IS, and interaction of isolated granules with F-actin were all decreased. Similarly, inhibition of myosin function also diminished the penetration of lytic ...
2a, b). Granzyme B+ granules were larger in γδD4 T cells (Fig. 2c and Supplementary Fig. 2c) but no difference in shape was noticed (Supplementary Fig. 2d). However, there was no strong correlation between granule size and granzyme B loading (Supplementary Fig. 2e). Interestingly, ...
The lytic granules of natural killer cells are dual-function organelles combining secretory and pre-lysosomal compartments. J. Cell Biol. 111, 2327–2340 (1990). Article CAS PubMed Google Scholar Zhang, X. et al. Talin depletion reveals independence of initial cell spreading from integrin ...
function as spatial cues to attract lytic granules containing perforin and granzyme and induce their fusion with the plasma membrane for content release. LFA-1 is subjected to pulling forces within secretory domains, and disruption of these forces via depletion of the adaptor molecule talin abrogates...
1Introduction Cytotoxic T lymphocytes (CTLs) are the T cell effectors specialized for the elimination of cells infected by intracellular pathogens as well as cancerous cells. CTLs exert their cytotoxic function through two well-characterized cytotoxic mechanisms: release of cytotoxic granules (CG) and...
Invasion is an active process involving many parasite functions and is accompanied by the sequential discharge of several distinct intracellular compartments including the micronemes, rhoptries, and dense granules. The contents of these compartments serve many functions. Among these, it is presumed that...
Interference of Stx7 function by expression of a dominant-negative Stx7 construct or by small interfering RNA leads to a dramatic reduction of CTL-mediated killing of target cells. Real-time visualization of individual lytic granules at the IS by evanescent wave microscopy reveals that lytic ...
This defines a novel mechanism for myosin II function, in which myosin IIA can act as a single-molecule actin motor, claiming granules as cargo through tail-dependent phosphorylation for the execution of a pre-final step in human NK-cell cytotoxicity. 展开 关键词: phosphorylation cytotoxicity NK...
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