Paul M. GallopElsevier Inc.Biochemical & Biophysical Research CommunicationsChen KH, Evans CA, Gallop PM: Prolyl and lysyl hydroxylase activation and cofactor specificity in young and senescent WI-38 fibroblast cultures. Biochem Biophys Res Commun 74:1631-1636, 1977...
Essential roles of insulin, AMPK signaling and lysyl and prolyl hydroxylases in the biosynthesis and multimerization of adiponectin Lin Zhang a , Ming-Ming Li a , Marie Corcoran a , Shaoping Zhang a , Garth J.S. Cooper a,b,c,d,e, * a School of Biological Sciences and Maurice Wilkins...
This review also demonstrates the potential for further study into this area to provide more subtle information into the mechanisms and etiology of disease ... L Knott,AJ Bailey - 《Bone》 被引量: 961发表: 1998年 Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and...
Here we report that the transcription factor GATA3 and its co-factor FOG2 commonly promote the expression of the lysyl hydroxylase (LH) family members, including LH2 and LH3, which in turn drive lung adenocarcinoma cell migration, invasion, and metastasis. We show evidence that both LH2 and ...
These enzymes are known to act together with prolyl hydroxylases, respectively introducing hydroxylations of lysine and proline residues on procollagens in the endoplasmic reticulum (ER), prior to the formation of triple-helical assemblies20. In line with this, LH enzymes are found as ER-...
These enzymes are known to act together with prolyl hydroxylases, respectively introducing hydroxylations of lysine and proline residues on procollagens in the endoplasmic reticulum (ER), prior to the formation of triple-helical assemblies20. In line with this, LH enzymes are found as ER-...
Collagens, the most abundant proteins in animals, are modified by hydroxylation of proline and lysine residues and by glycosylation of hydroxylysine. Dedicated prolyl hydroxylase, lysyl hydroxylase, and collagen glycosyltransferase enzymes localized in the endoplasmic reticulum mediate these modifications prior...
I. Prolyl hydroxylase. Eur J Clin Invest 9:89–95 Google Scholar Kuutti-Savolainen E-R, Anttinen H, Miettinen TA Kivirikko KI (1979a) Collagen biosynthesis enzymes in serum and hepatic tissue in liver disease. II. Galactosylhydroxylysyl glucosyltransferase. Eur J Clin Invest 9:97–101 ...
Under normoxia, prolyl hydroxylase domain-containing proteins (PHD1–3) hydroxylate HIF-1α at P402 and P564, leading to pVHL-mediated poly-ubiquitination and subsequent degradation of HIF-1α. In addition, the transcriptional activity of HIF-1α is oxygen-dependently controlled through the FIH-...
Prolyl 4-hydroxylases catalyze the formation of 4-hydroxyproline in collagens and other proteins with an appropriate collagen-like stretch of amino acid re... KI Kivirikko,T Pihlajaniemi - 《Adv Enzymol Relat Areas Mol Biol》 被引量: 478发表: 1998年 The primary structure and structural chara...