Prolyl 3-hydroxylase 1 deficiency causes a recessive meta- bolic bone disorder resembling lethal/severe osteogenesis imper- fecta. Nat Genet 2007;39:359-65.Cabral WA, Chang W, Barnes AM, Weis M, Scott MA, Leikin S, Makareeva E, Kuznetsova NV, Rosenbaum KN, Tifft CJ, Bulas DI, Kozma C...
Type I collagen extracted from tendon, skin, and bone of wild type and prolyl 3-hydroxylase 1 (P3H1) null mice shows distinct patterns of 3-hydroxylation and glycosylation of hydroxylysine residues. The A1 site (Pro-986) in the alpha 1-chain of type I collagen is almost completely 3-hydro...
The Prolyl 3-Hydroxylases P3H2 and P3H3 are novel targets for epigenetic silencing in breast cancer. Br J Cancer 2009;100:1687-96... SE Mcguire - 《Breast Diseases A Year Book Quarterly》 被引量: 0发表: 2009年 Nickel carcinogenesis: epigenetics and hypoxia signaling. Both water soluble and...
Sequence Determinants in Hypoxia-inducible Factor-1α for Hydroxylation by the Prolyl Hydroxylases PHD1, PHD2, and PHD3 Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor induced by hypoxia. Under normoxic conditions, site-specific proline hydroxylation o... J Huang,Q Zhao,SM...
141: Prolyl-3 Hydroxylase Expression in the Mouse Kidney and Developing Embryo - American Journal of Kidney Diseasesdoi:10.1053/j.ajkd.2008.02.149Jennifer LenningtonRoy MorelloMing-Ming JiangDustin BaldridgeTerry BertinBrendan LeeElsevier Inc.American Journal of Kidney Diseases...
Poly(ADP-ribose) prepared by incubating NAD+ with rat liver nuclei inhibited the hydroxylation reaction catalyzed by purified prolyl hydroxylase (proline,2-oxoglutarate dioxygenase, EC 1.14.11.2) in vitro. Near complete inhibition of the enzyme was seen in the presence of 6 nM (ADP-Rib)18 with...
Collagen and collagen-associated proteins studies on the type XV trimerization domain, prolyl 3-hydrolase and the prolyl 3-hydroxylase cartilage associated protein cyclophilin B complex 来自 Semantic Scholar 喜欢 0 阅读量: 35 作者: Jacqueline A Wirz 摘要: iv List of Figures and Tables v ...
The prolyl hydroxylase 3 (PHD3) belongs to the family of 2-oxoglutarate and iron-dependent dioxygenases, which could hydroxylate the proline residues of hypoxia inducible factor 1α (HIF-1α) causing proteasomal degradation via combination with the von Hippel-Lindau protein (pVHL) ubiquitin ligase...
James J.1 Molecular and Cellular Biology ProgramPLoS ONEPlace TL, Nauseef JT, Peterson MK, Henry MD, Mezhir JJ, Domann FE. Prolyl-4-hydroxylase 3 (PHD3) expression is downregulated during epithelial-to-mesenchymal transition. PLoS One. 2013; 8 :e83021....
化学性质 安全信息 用途 供应商 1 EGLN2 (Egl Nine Homolog 2, Hypoxia-inducible Factor Prolyl Hydroxylase 1, HIF-prolyl Hydroxylase 1, HIF-PH1, HPH-3, Prolyl Hydroxylase Domain-containing Protein 1, PHD1, Estrogen-induced Tag 6, EIT6, DKFZp434E026) (MaxLight 550)化学性质...