Place, T. L. and Domann, F. E. (2013) Prolyl-hydroxylase 3: Evolving Roles for an Ancient Signaling Protein. Hypoxia (Auckl). 2013, 13-17Place TL and Domann FE. Prolyl-hydroxylase 3: Evolving Roles for an Ancient Signaling Protein. Hypoxia (Auckl). 2013; 2013:13-17....
The prolyl hydroxylase 3 (PHD3) belongs to the family of 2-oxoglutarate and iron-dependent dioxygenases, which could hydroxylate the proline residues of hypoxia inducible factor 1α (HIF-1α) causing proteasomal degradation via combination with the von Hippel-Lindau protein (pVHL) ubiquitin ligase...
The effects are independent of HIF1α but dependent on the presence of PHD3. These data suggest that PHD3 may be a valid target in vivo for anti-tumor therapy. 展开 关键词: Hypoxia Prolyl hydroxylase Cancer Apoptosis DOI: 10.1007/s00109-010-0627-0 ...
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Purification and Characterization of Prolyl Hydroxylase 3/Pyruvate Kinase Isoform 2 Protein ComplexThe prolyl hydroxylase 3 (PHD3) protein is less abundant in normal oxygen conditions (normoxia) but increases under deficient oxygen condition (hypoxia). Since cancerous cells often thrive in hypoxic ...
141: Prolyl-3 Hydroxylase Expression in the Mouse Kidney and Developing Embryo - American Journal of Kidney Diseasesdoi:10.1053/j.ajkd.2008.02.149Jennifer LenningtonRoy MorelloMing-Ming JiangDustin BaldridgeTerry BertinBrendan LeeElsevier Inc.American Journal of Kidney Diseases...
Prolyl-4-hydroxylase 3 (PHD3) expression is downregulated during epi- thelial-to-mesenchymal transition. PLoS One 2013;8:e83021.Place TL, Nauseef JT, Peterson MK, Henry MD, Mezhir JJ, Domann FE. Prolyl-4-hydroxylase 3 (PHD3) expression is downregulated during epithelial-to-mesenchymal ...
The Prolyl 3-Hydroxylases P3H2 and P3H3 are novel targets for epigenetic silencing in breast cancer. Br J Cancer 2009;100:1687-96... SE Mcguire - 《Breast Diseases A Year Book Quarterly》 被引量: 0发表: 2009年 Nickel carcinogenesis: epigenetics and hypoxia signaling. Both water soluble and...
Differences between prolyl 3-hydroxylase and prolyl 4-hydroxylase activities were found in their stimulation and inactivation by dithiothreitol and in their affinity to poly-L-proline linked to agarose. The two enzyme activities were separated by gel filtration, the results demonstrating that they are...
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